Resuspendable coated magnetic particles and stable magnetic particle suspensions
AssigneeImmunivest Corporation
InventorsPaul A. Liberti, Maria A. Pino
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Abstract
Stable suspensions of coated magnetic particles, preferably resuspendable bioactive particles particularly useful in Magnetic Resonance Imaging, are produced by disrupting, what are presumed to be, crystalline agglomerates of a parent particulate magnetic starting material in the presence of a coating material, such that coating can take place during the disruption. The particles are generally coated in suspension yielding a stable suspension of subdivided particles. With the proper selection of a coating material, preferably a protein or other biochemically or biologically active polymer such as an antibody, a resuspendable (colloidal) bioactive product is obtained.
Claims24
A process for making resuspendable coated magnetic particles, said process comprising:
- a. forming a liquid mixture of a particulate magnetic starting material and a coating material characterized by the ability to form a coating on disrupted particles of said magnetic starting material,
- b. treating said mixture to subdivide the particles of said magnetic starting material,
- c. simultaneously with step b., permitting said coating material to form a coating on the subdivided particles of said magnetic starting material to form stable, resuspendable coated particles of said magnetic starting material,
- d. recovering the resuspendable coated magnetic particles from the liquid mixture.
A process for making a stable suspension of resuspendable magnetic particles, said process comprising:
- a. forming a liquid mixture of a particulate magnetic starting material and a coating material characterized by the ability to stabilize disrupted particles of said magnetic starting material,
- b. sonicating said mixture to disrupt the particles of said magnetic starting material and,
- c. simultaneously with step b., permitting said coating material to form a coating on the disrupted particles of said magnetic starting material, forming a stable suspension thereof.
A magnetically responsive coated microparticle in which the core comprises oxides of at least two different transition metals and the resultant coated particle is colored white at equilibrium in a stable suspension.
Dependencies are inferred from the claim text.