Salts of amino glycosides
AssigneeDumex-Alpharma A/S
InventorsHjarne Dyrsting, Torben Koch
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Abstract
The present invention relates to novel amino glycoside salts of sucrose-octa-O-sulfonic acid of formula I: ([sucrose-octa-O-sulfonic acid.sup.8- ]-[R-(NH.sub.3.sup.+).sub.x ].sub.y -M.sub.z.sup.n+) (I) (x.multidot.y)+(z.multidot.n)=8 x.multidot.y.epsilon.N.vertline.[4.ltoreq.x.multidot.y.ltoreq.8], wherein N is the set of natural numbers, x.epsilon.Z.vertline.[4.ltoreq.x.ltoreq.6], wherein Z is the set of integers z.epsilon.N.vertline.[0.ltoreq.z.ltoreq.4], n.epsilon.Z.vertline.[1.ltoreq.n.ltoreq.3], wherein R is a sugar moiety of an amino glycoside and M is a metal ion or an ammonium ion, said compounds being useful for treating ulcerations of the stomach and duodenum.
Claims6
A compound of the formula (I):
- ([sucrose-octa-O-sulfonic acid.sup.8- ]-[R-(NH.sub.3.sup.+).sub.x ].sub.y -M.sub.z.sup.n+) (I)
- wherein
- (x.multidot.y)+(z.multidot.n)=8
- x.multidot.y.epsilon.N.vertline.[4.ltoreq.x.multidot.y.ltoreq.8], wherein N is the set of natural numbers,
- x.epsilon.Z.vertline.[4.ltoreq.x.ltoreq.6], wherein Z is the set of integers
- z.epsilon.N.vertline.[0.ltoreq.z.ltoreq.4],
- n.epsilon.Z.vertline.[1.ltoreq.n.ltoreq.3],
- wherein R is a sugar moiety of an amino glycoside and M is selected from the group consisting of alkali metal ions, alkaline earth metal ions, an aluminum ion and an ammonium ion, or a pharmaceutically acceptable salt thereof.
A method of treating gastritis and ulcerations caused by H. pylori in at least one location selected from the stomach and the duodenum in a warm-blooded animal, comprising administering to said warm-blooded animal a gastritis treating or ulceration treating effective amount of a compound of formula I:
- ([sucrose-octa-O-sulfonic acid.sup.8- ]-[R-(NH.sub.3.sup.+).sub.x ].sub.y -M.sub.z.sup.n+) (I)
- wherein
- (x.multidot.y)+(z.multidot.n)=8
- x.multidot.y.epsilon.N.vertline.[4.ltoreq.x.multidot.y.ltoreq.8], wherein N is the set of natural numbers,
- x.epsilon.Z.vertline.[4.ltoreq.x.ltoreq.6], wherein Z is the set of integers
- z.epsilon.N.vertline.[0.ltoreq.z.ltoreq.4],
- n.epsilon.Z.vertline.[1.ltoreq.n.ltoreq.3],
- wherein R is a sugar moiety of an amino glycoside and M is selected from the group consisting of alkali metal ions, alkaline earth metal ions, an aluminum ion and an ammonium ion, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.