Compound with platelet aggregation inhibitor activity

A compound represented by the formula (I) or a pharmaceutically acceptable salt and solvate thereof:

• ##STR63## wherein R.sup.1 represents a group --W--(CH.sub.2).sub.i -COOR.sup.3, where W represents --O-- or a bond, R.sup.3 represents hydrogen, lower alkyl, C.sub.5-7 cycloalkyl or an ester moiety which may be removed under a physiological condition, and i is an integer from 1 to 4,
• R.sup.2 represents hydrogen or a group --W--(CH.sub.2).sub.i -COOR.sup.3, where W, R.sup.3 and i have the same meanings as defined above, or a group --OR.sup.4, where R.sup.4 represents hydrogen, lower alkyl, mono lower alkylaminocarbonyl or phenyl-lower alkyl,
• X represents CH or N,
• Y represents
• (i) a group --(CO).sub.k --N(R.sup.5)--Z--,
• where k represents 0 or 1,
• R.sup.5 represents hydrogen;
• lower alkyl;
• or acyl,
• Z represents a bond, or a group --(CH.sub.2).sub.m --CO-- or a group --(CH.sub.2).sub.m --CHR.sup.6 --, where m is an integer from 1 to 3 and R.sup.6 represents hydrogen or hydroxyl,
• (ii) a group --CO--(CH.sub.2).sub.m --N(R.sup.5)--(CO).sub.k --
• where k, m and R.sup.5 have the same meanings as defined above, or
• (iii) a group --(CO).sub.k -Het
• where Het represents a five-membered heterocyclic ring containing 1 to 4 nitrogen atoms, or a six-membered ring which has 1 or 2 nitrogen atoms, which may optionally contain an oxygen atom or a sulfur atom when the ring contains 1 or 2 nitrogen atoms, and
• where k has the same meaning as defined above,
• A represents
• (i) the following group (III):
• ##STR64## wherein R.sup.9 represents hydrogen;
• lower alkyl in which one or more hydrogen atoms may be substituted by hydroxyl, halogen, amino or lower alkyl amino;
• or amidino, or
• (ii) the following group (IV):
• ##STR65## wherein R.sup.9 has the same meanings as defined above,
• one of E or H represents --NR.sup.10 --, --O-- or --S-- and the other represents a bond, F and G represent --CR.sup.10 --, where R.sup.10 represents hydrogen, lower alkyl or phenyl-lower alkyl, p and q independently are 1 or 2 provided that p+q is 3, and
• B represents a bond, C.sub.1-6 alkylene or C.sub.2-6 alkenylene.