Methods and compositions for inhibition of angiogenesis

A method of treating chronic inflammation in a human or animal comprising the step of administering to the human or animal with the chronic inflammation a composition comprising an epoxide hydrolase inhibitor and an effective amount of an angiogenesis-inhibiting compound selected from the group consisting of the following compounds:

• ##STR20## In the above formulae A), B), and C), R.sub.1, R.sub.2, R.sub.3 and R.sub.4 can be selected from:
• --H;
• --OH;
• .dbd.O, straight chained and branched alkanes, alkenes, alkynes;
• cyclic alkanes, alkenes, and alkynes;
• combinations of cyclic and acyclic alkanes, alkenes, and alkynes;
• alcohol, aldehyde, ketone, carboxylic acid, ester, or ether moieties in combination with acyclic, cyclic, or combination acyclic/cyclic moieties;
• aza;
• amino;
• --XO.sub.n or --O--XO.sub.n, where X=N and n=2;
• X=S and n=2 or 3;
• or X=P and n=1-3;
• and halogens;
• R.sub.5, R.sub.6, R.sub.7, and R.sub.8 are each independently selected from:
• ##STR21## or --O-- where Y is optional and is the same as defined above for R.sub.1 ;
• and R.sub.10 is the same as defined above for R.sub.1, or where Y is absent R.sub.10 is .dbd.O;
• and R.sub.9 is a moiety having formula D), E), F), G) or H):
• ##STR22## where each of R.sub.11 -R.sub.17 is independently the same as defined above for R.sub.5 ;
• ##STR23## where R.sub.18, R.sub.19 and R.sub.20 are, independently selected from ##STR24## and n=1 to 4.