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US 5,593,866 AGranted
Cationic peptides and method for production
AssigneeThe University of British Columbia
InventorsRobert E. W. Hancock, Kevin L. Piers, Melissa H. Brown
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Abstract
A method for the microbial production of a cationic peptide having anti-microbial activity is provided, wherein the cationic peptide is first produced as a fusion protein having an anionic portion for suppressing the antimicrobial activity of the cationic portion. A novel cationic peptide having anti-microbial activity is also provided.
Claims19
A method of producing a biologically active cationic peptide which has antimicrobial activity comprising:
- a) constructing an expression vector containing a DNA sequence encoding the cationic peptide adjacent to a DNA sequence encoding an anionic carrier peptide, wherein the anionic carrier peptide inhibits bacterial proteases;
- b) transforming a bacterial host cell with the vector of a) and culturing the transformed host cell such that a fusion peptide comprising the cationic peptide and anionic peptide is expressed and;
- c) recovering the biologically active cationic peptide.
Dependencies are inferred from the claim text.