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US 5,593,853 AGranted
Generation and screening of synthetic drug libraries
AssigneeMartek Corporation
InventorsHao Chen, Richard Radmer
Life of this patent
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Abstract
Methods are provided for generating highly diverse mixtures of compounds which may be screened for biological activities. Once the activity is found, the component of the mixture which is responsible for the activity can be isolated by fractionation and assay for the biological activity. Polyhydroxylated organic monomers and oligomers are used as starting materials for generating the libraries.
Claims59
A method for generating and screening a library of compounds, comprising:
- reacting one or more polyhydroxyl-containing organic compounds with subequimolar amounts of displacing groups to form a first mixture comprising displacing group-substituted polyhydroxyl-containing organic compounds;
- testing said first mixture or a reaction product made therefrom for the presence of a component displacing group-substituted polyhydroxyl-containing organic compound in said first mixture or said reaction product having a biological activity;
- fractionating said mixture or reaction product which demonstrates biological activity to form fractions;
- testing said fractions for said biological activity.
1 more element
A method for generating and screening a library of compounds, comprising:
- reacting one or more polyhydroxyl-containing organic compounds with subequimolar amounts of protecting groups to form a first mixture of randomly protected polyhydroxyl-containing organic compounds;
- oxidizing said first mixture to form a second mixture comprising carbonyl-containing organic compounds;
- testing said first or said second mixtures or a reaction product made therefrom for the presence of a component randomly protected polyhydroxyl-containing organic compound or carbonyl-containing organic compound having a biological activity;
- fractionating said first or second mixture or a reaction product made therefrom which demonstrates biological activity to form fractions;
- testing said fractions for said biological activity.
2 more elements
Dependencies are inferred from the claim text.