Compositions and methods for treating wounds

A wound-treatment gel formulation comprising amounts of at least two non-steroidal anabolic hormones selected from the group consisting of insulin, growth hormone, triiodothyronine and thyroxine effective to enhance the healing of a skin wound in animals in combination with a cellular nutrient medium comprising essential amino acids, non-essential amino acids, a mixture of vitamins comprising amounts of folate, niacinamide, pantothenate, pyridoxine, riboflavin and thiamin, a mixture of inorganic ions comprising calcium, sodium, potassium, magnesium and chloride and glucose in amounts effective to enhance the healing of said wound in combination with said anabolic hormones, said formulation also including water and at least one polymer selected from the group consisting of polyhydroxyethylmethacrylate, polyvinylpyrrolidone, polyethylene glycol, gelatin, sepharose, agarose, collagen, cellulose, dextran, polyethyleneoxide, dextran-polyethylene, polyacrylamide, amylose, a hydrophilic cellulose polymer and mixtures thereof in amounts effective to form a gel for application of said formulation to said wound.

A wound-treatment gel formulation comprising a mixture of non-steroidal anabolic hormones selected from at least two of the group consisting of insulin, triiodothyronine and thyroxine in an amount effective to enhance the healing of skin wounds in animals in combination with a cellular nutrient medium comprising essential amino acids, non-essential amino acids, a mixture of vitamins comprising amounts of folate, niacinamide, pantothenate, pyridoxine, riboflavin and thiamin, a mixture of inorganic ions comprising calcium, sodium, potassium, magnesium and chloride and glucose in amounts effective to enhance the healing of said wounds in combination with said anabolic hormones, said formulation also including water and at least one polymer selected from the group consisting of polyhydroxyethylmethacrylate, polyvinylpyrrolidone, polyethylene glycol, gelatin, sepharose, agarose, collagen, cellulose, dextran, polyethyleneoxide, dextran-polyethylene, polyacrylamide, amylose, a hydrophilic cellulose polymer and mixtures thereof in amounts within a range of about 1% to about 20% by weight of said formulation effective to form a gel for application of said formulation to a skin wound.

A method for treating skin wounds in animals comprising applying to said wound a formulation comprising an amount of a non-steroidal anabolic hormone selected from the group consisting of insulin, triiodothyronine, thyroxine and mixtures thereof effective to enhance the healing of said wounds in combination with a nutrient medium comprising essential amino acids, non-essential amino acids, a mixture of vitamins comprising amounts of folate, niacinamide, pantothenate, pyridoxine, riboflavin and thiamin, a mixture of inorganic ions comprising calcium, sodium, potassium, magnesium and chloride and glucose in amounts effective to enhance the healing of said wounds in combination with said anabolic hormone.

A wound-treatment gel formulation comprising a mixture of insulin, growth hormone and at least one additional anabolic hormone selected from the group consisting of triiodothyronine, thyroxine and mixtures thereof, said insulin, growth hormone and additional anabolic hormone being included in said formulation in an amount effective to enhance the healing of skin wounds in animals in combination with a cellular nutrient medium comprising essential amino acids, non-essential amino acids, a mixture of vitamins comprising amounts of folate, niacinamide, pantothenate, pyridoxine, riboflavin and thiamin, a mixture of inorganic ions comprising calcium, sodium, potassium, magnesium and chloride and glucose in amounts effective to enhance the healing of said wounds in combination with said insulin, growth hormone and additional anabolic hormone, said formulation also including water and at least one polymer selected from the group consisting of polyhydroxyethylmethacrylate, polyvinylpyrrolidone, polyethylene glycol, gelatin, sepharose, agarose, collagen, cellulose, dextran, polyethyleneoxide, dextran-polyethylene, polyacrylamide, amylose, a hydrophilic cellulose polymer and mixtures thereof in an amount effective to form a gel for application of said formulation to a skin wound.

A method for treating skin wounds in animals comprising applying to said wound a formulation comprising a wound-healing effective amount of a non-steroidal anabolic hormone selected from the group consisting of insulin, triiodothyronine, thyroxine and mixtures thereof in combination with a serum free nutrient medium selected from the group consisting of F10, F12, Basal Medium Eagle including Earle's salt base, Dulbecco's Modified Eagle Medium, McCoy's 5A Medium, MCDB 153, Medium M199 including Earle's salt base, Medium M199 including Hank's salt base, Minimum Essential Medium Eagle including Earle's salt base, Minimum Essential Medium Eagle including Hank's salt base, Minimum Essential Medium Eagle with non-essential amino acids and mixtures thereof in amounts effective to enhance the healing of said wounds in combination with said anabolic hormone.

A wound-treatment formulation comprising a mixture of insulin, growth hormone and at least one additional anabolic hormone selected from the group consisting of triiodothyronine, thyroxine and mixtures thereof, said insulin, growth hormone and additional anabolic hormone being included in said formulation in an amount effective to enhance the healing of skin wounds in animals in combination with a cellular nutrient medium comprising essential amino acids, non-essential amino acids, a mixture of vitamins comprising amounts of folate, niacinamide, pantothenate, pyridoxine, riboflavin and thiamin, a mixture of inorganic ions comprising calcium, sodium, potassium, magnesium and chloride and glucose in amounts effective to enhance the healing of said wounds in combination with said insulin, growth hormone and additional anabolic hormone, said formulation also including at least one polymer selected from the group consisting of polyhydroxyethylmethacrylate, polyvinylpyrrolidone, polyethylene glycol, gelatin, sepharose, agarose, collagen, cellulose, dextran, polyethyleneoxide, dextran-polyethylene, polyacrylamide, amylose, a hydrophilic cellulose polymer and mixtures thereof in an amount effective to form a gel in combination with water for application of said formulation to a skin wound.

A wound-treatment formulation comprising a mixture of insulin, growth hormone and at least one additional anabolic hormone selected from the group consisting of triiodothyronine, thyroxine and mixtures thereof, said insulin, growth hormone and additional anabolic hormone being included in said formulation in an amount effective to enhance the healing of skin wounds in animals in combination with a cellular nutrient medium selected from the group consisting of F10, F12, Basal Medium Eagle including Earle's salt base, Dulbecco's Modified Eagle Medium, McCoy's 5A Medium, MCDB 153, Medium M199 including Earle's salt base, Medium M199 including Hank's salt base, Minimum Essential Medium Eagle including Earle's salt base, Minimum Essential Medium Eagle including Hank's salt base, Minimum Essential Medium Eagle with non-essential amino acids and mixtures thereof, said formulation also including at least one polymer selected from the group consisting of polyhydroxyethylmethacrylate, polyvinylpyrrolidone, polyethylene glycol, gelatin, sepharose, agarose, collagen, cellulose, dextran, polyethyleneoxide, dextran-polyethylene, polyacrylamide, amylose, a hydrophilic cellulose polymer and mixtures thereof in an amount effective to form a gel in combination with water for application of said formulation to a skin wound.