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US 5,591,438 AGranted
Natamycin recovery
AssigneeBio-Technical Resources
InventorsPhillip T. Olson, James R. Millis, Michael H. Reimer
Life of this patent
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AssigneeBio-Technical Resources
InventorsPhillip T. Olson, James R. Millis, Michael H. Reimer
Estimating the term…
A process for the recovery of high purity natamycin from fermentaion broth by extraction with methanol is disclosed. In one embodiment the process comprises the steps: (1) adding methanol to a natamycin feed stream comprising at least 2 g/L of solid suspended natamycin to form an extraction medium, and maintaining the extraction medium at a temperature of 0.degree.-25.degree. C., preferably not over 15.degree. C.; (2) adjusting the pH of the extraction medium to 1.0 to 4.5 while maintaining the temperature at 0.degree.-25.degree. C. for 0.5 to 30 hours, but preferably not over 0.5 hours when the temperature is 15.degree.-25.degree. C.; (3) removing solids from the extraction medium to form an extraction liquor; (4) raising the pH of the extraction liquor to 6.0-9.0; and (5) recovering precipitated natamycin.
A process for the recovery of natamycin from natamycin fermentation broth comprising in order the following steps:
A process for the recovery of natamycin from natamycin fermentation broth comprising in order the following steps:
A process for the recovery of natamycin from natamycin fermentation broth comprising in order the following steps:
Dependencies are inferred from the claim text.