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US 5,589,490 AGranted
Benzoic acid substituted derivatives having cardiovascular activity
AssigneeItalfarmaco S.p.A.
InventorsAlberto Sala, Aldo Banfi, Francesca Benedini, Roberta Cereda
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Abstract
The abstract isn’t available for this document.
Claims11
A compound of the formula I ##STR8## wherein:
- X is the NH group;
- Y is an ethylene or a C.sub.3 -C.sub.6 straight or branched alkylene, or a cyclopentylene, cyclohexylene or cycloheptylene group;
- R.sub.1 is the OCOR.sub.3 group, wherein R.sub.3 is methyl, ethyl or C.sub.3 -C.sub.5 straight or branched alkyl, or the residue from a 5- or 6-membered monocyclic heterocycle which can be aromatic or partially or totally hydrogenated, containing one or more hetero-atoms selected independently from O, N and S;
- R.sub.2 is hydrogen, hydroxy, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trifluoromethyl, sulfo, nitro, amino, or mono- or di- C.sub.1-4 alkylamino;
- or
- R.sub.1 and R.sub.2, taken together, are the methylenedioxy group;
- with the proviso that when Y is ethylene and R.sub.2 is hydrogen, R.sub.1 cannot be the OCOR.sub.3 group at the 2- position in which R.sub.3 is methyl;
- and the pharmaceutically acceptable acid salts thereof.
5 more elements
The compound selected from the group consisting of 4-acetoxy-N-(2-nitroxyethyl)-benzamide and N-(2-nitroxyethyl)-2-[4-thiazolidinyl)carboxyloxy]-benzamide hydrochloride.
A compound of the formula I ##STR9## wherein X is an oxygen atom;
- Y is an ethylene or a C.sub.3 -C.sub.6 straight or branched alkylene, or a cyclopentylene, cyclohexylene or cycloheptylene group;
- R.sub.1 is the OCOR.sub.3 group, wherein R.sub.3 is methyl, ethyl or C.sub.3 -C.sub.5 straight or branched alkyl or the residue from a 5- or 6-membered monocyclic heterocycle which can be aromatic or partially or totally hydrogenated, containing one or more hetero-atoms selected independently from O, N and S;
- R.sub.2 is hydrogen, hydroxy, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trifluoromethyl, sulfo, nitro, amino, mono- or di- C.sub.1-4 alkylamino;
- or
- R.sub.1 and R.sub.2, taken together, are the methylenedioxy group;
- and the pharmaceutically acceptable acid salts thereof.
3 more elements
Dependencies are inferred from the claim text.