US 5,589,182 AGranted

Compositions and method of treating cardio-, cerebro-vascular and alzheimer's diseases and depression

OwnerRenki Tashiro, Ruth H. Paterinventors

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Abstract

A pharmaceutical composition suitable for the treatment of a condition selected from the group consisting of cardiovascular disease, cerebrovascular disease, Alzheimer's disease, depression or combinations thereof comprising various mixtures of the aqueous extracts of tissue of specific Chinese plants and herbs. A method of preparing the pharmaceutical compositions of the invention and a method for treating a patient therewith are also disclosed.

Claims35

Dependent claims

A pharmaceutical composition in unit dosage form suitable for the treatment of a condition selected from the group consisting of cardiovascular disease and cerebrovascular disease comprising a therapeutically effective amount of a member selected from the group consisting of:

I. a mixture of aqueous extracts of:
a. root tissue of the plant Asparagus cochinchinensis containing asparagine, .beta.-sitosterol and 5-methoxymethylfurfural,
b. root tissue of the plant Ophiopogon japonicus containing glucose, starch, vitamin A and .beta.-sitosterol,
c. root tissue of the plant Salvia miltiorrhiza containing tanshinone A C.sub.18 H.sub.12 O.sub.3, tanshinone B C.sub.19 H.sub.18 O.sub.3 and tanshinone C C.sub.19 H.sub.20 O.sub.3,
d. root tissue of the plant Angelica aeutiloba kitagawa containing ligustillide,
e. root tissue of the plant Rehmannia glutinosa Liboschitz containing rehmannin, xylitol, glucose, mannitol, iron, vitamin A and catalpol,
f. white stone-like material formed by bacteria on surface of underground root of tree Poria cocos wolf containing ergosterol,
g. ripe fruits of the plant Schizandra chinensis containing citral, schizandrin C.sub.23 H.sub.32 O.sub.6, vitamin A, vitamin C and d-ylangene,
h. root tissue of the plant Platycodon grandiflorum containing polygalacic acid platycoside, inulin and phytosterol,
i. root tissue of the plant Polygala tenuifolia containing tenuifolin, polygallitol C.sub.6 H.sub.12 O.sub.5 and onsicin C.sub.24 H.sub.47 O.sub.5,
j. dried seeds of the plant Zizyphus jujuba containing betulinic acid C.sub.30 H.sub.48 O.sub.3, betulin C.sub.30 H.sub.50 O.sub.2, .beta.-sitosterol, fatty acids, vitamin A and organic acids,
k. dried seeds of the plant Biota orientalis containing borneol and fatty acids,
1. root tissue of the plant Pueraria pseudo-hirsuta containing flavon, puerarin and daidzein,
m. root tissue of the plant Panax ginseng containing ginsenoside, panacene C.sub.15 H.sub.24, panaquilon C.sub.32 H.sub.56 O.sub.14, panaxin C.sub.23 H.sub.38 O.sub.10, organic acids, vitamin A, vitamin B.sub.1, vitamin B.sub.2, vitamin C, inorganic salts and starch,
n. root tissue of the plant Codonopsis pilosula containing alkaloid, saponin, protein, starch, vitamin B.sub.1 and vitamin B.sub.2,
o. root tissue of the plant Scrophularia ningpoensis containing harpagide, phytosterol, linoleic acid and alkaloid,
p. root tissue of the plant Glycyrrhiza uralensis containing glycyrrhizic acid, calcium salt, potassium salt, glycyrrhizin, glycyrrhizic acid, liquiritigenin C.sub.21 H.sub.22 O.sub.9, glucose, mannitol, malic acid and l-asparagine,
q. root tissue of the plant Panax pseudo-ginseng containing pseudo-ginseng A C.sub.30 H.sub.52 O.sub.10, pseudo-ginseng B C.sub.23 H.sub.38 O.sub.10 and flavon,
r. the whole plant Ganoderma japonicum containing amino acid, protein, sterol and alkaloid,
s. root tissue of the plant Coptis chinensis containing berberine C.sub.20 H.sub.19 O.sub.5 N, coptisine C.sub.19 H.sub.15 O.sub.5 N, palmatine C.sub.21 H.sub.23 O.sub.5 N and woorenine C.sub.20 H.sub.17 O.sub.5 N,
t. flower heads of the plant Chrysanthemum morifolium containing adenine C.sub.5 H.sub.5 N.sub.5, stachydrine C.sub.7 H.sub.13 NO, choline and oil, and
u. skins of the plant Phellodendron amurense containing berberine, obakunone C.sub.26 H.sub.30 O.sub.7, obakulactone C.sub.26 H.sub.30 O.sub.8 and dictammolactone C.sub.28 H.sub.30 O.sub.9 ;
II. a mixture of the aqueous extracts of:
I.a.,
I.b.,
I.c.,
I.d.,
I.e.,
I.f.,
I.g.,
I.h.,
I.i.,
I.k.,
I.l.,
I.m.,
I.n.,
I.o.,
I.p.,
I.q., and
I.r.;
III. a mixture of the aqueous extracts of:
I.a.,
I.b.,
I.c.,
I.d.,
I.e.,
I.f.,
I.g.,
I.h.,
I.i.,
I.k.,
I.l.,
I.m.,
I.o.,
I.p.,
I.r.,
I.s.,
I.t.;
and
IV. a mixture of finely divided:
1. root tissue of the plant Salvia miltiorrhiza containing tanshinone A C.sub.18 H.sub.12 O.sub.3, tanshinone B C.sub.19 H.sub.18 O.sub.3 and tanshinone C C.sub.19 H.sub.20 O.sub.3,
2. root tissue of the plant Panax pseudo-ginseng containing ginsenoside, panacene C.sub.15 H.sub.24, panaquilon C.sub.32 H.sub.56 O.sub.14, panaxin C.sub.23 H.sub.38 O.sub.10, organic acids, vitamin A, vitamin B.sub.1, vitamin B.sub.2, vitamin C, inorganic salts and starch,
3. root tissue of the plant Red ginseng containing ginsenoside, panacene C.sub.15 H.sub.24, panaquilon C.sub.32 J.sub.56 O.sub.14, panaxin C.sub.23 H.sub.38 O.sub.10, organic acids, vitamin A, vitamin B.sub.1, vitamin B.sub.2, vitamin C, inorganic salts and starch, and
4. Amber, a hard translucent fossil resin buried between roots of old trees, containing succinoabietinolic acid C.sub.40 H.sub.60 O.sub.5, succinogiluinic acid C.sub.24 C.sub.36 O.sub.2, succinoresinol, succinoabietinol C.sub.40 H.sub.60 O and fatty acids,
wherein, in composition I, the weight percentage of each plant tissue, based on the total weight of said plants from which said mixture of aqueous extracts is derived, is in the range of:
from about 5% to about 20% of a.;
from about 5% to about 20% of b.;
from about 5% to about 20% of c.;
from about 5% to about 20% of d.;
from about 5% to about 20% of e.;
from about 5% to about 16% of f.;
from about 1% to about 15% of g.;
from about 1% to about 6% of h.;
from about 1% to about 10% of i.;
from about 1% to about 10% of j.;
from about 1% to about 10% of k.;
from about 1% to about 10% of l.;
from about 1% to about 10% of m.;
from about 1% to about 20% of n.;
from about 1% to about 15% of o.;
from about 0.1% to about 2% of p.;
from about 1% to about 15% of q.;
from about 1% to about 10% of r.;
from about 1% to about 5% of s.;
from about 1% to about 10% of t.;
and
from about 1% to about 10% of u.;
wherein, in composition II, the weight percentage of each plant tissue, based on the total weight of said plants from which said mixture of aqueous extracts is derived, is in the range of:
from about 3% to about 15% of a.;
from about 3% to about 15% of b.;
from about 5% to about 20% of c.;
from about 3% to about 15% of d.;
from about 5% to about 20% of e.;
from about 5% to about 20% of f.;
from about 2% to about 15% of g.;
from about 1% to about 5% of h.;
from about 2% to about 15% of i.;
from about 2% to about 15% of j.;
from about 2% to about 5% of k.;
from about 2% to about 15% of l.;
from about 1% to about 10% of m.;
from about 2% to about 15% of n.;
from about 3% to about 15% of o.;
from about 0.1% to about 2% of p.;
from about 3% to about 15% of q.;
and
from about 3% to about 15% of r.;
wherein, in composition III, the weight percentage of each plant tissue, based on the total weight of said plants from which said mixture of aqueous extracts is derived, is in the range of:
from about 5% to about 20% of a.;
from about 2% to about 10% of b.;
from about 2% to about 10% of c.;
from about 2% to about 10% of d.;
from about 2% to about 10% of e.;
from about 2% to about 10% of f.;
from about 2% to about 10% of g.;
from about 2% to about 4% of h.;
from about 2% to about 10% of i.;
from about 2% to about 10% of j.;
from about 1% to about 5% of k.;
from about 2% to about 10% of l.;
from about 2% to about 8% of m.;
from about 2% to about 15% of o.;
from about 0.1% to about 2% of p.;
from about 2% to about 10% of r.;
from about 1% to about 5% of s.;
and
from about 1% to about 5% of t.;
and wherein, in composition IV, the weight percentage of each plant tissue, based on the total weight of said plants from which said mixture of finely divided tissue is derived, is in the range of:
from about 20% to about 60% of 1.;
from about 20% to about 60% of 2.;
from about 10% to about 30% of 3.;
and
from about 5% to about 20% of 4.

130 more elements

Dependencies are inferred from the claim text.

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Abstract

I. a mixture of aqueous extracts of:
a. root tissue of the plant Asparagus cochinchinensis containing asparagine, .beta.-sitosterol and 5-methoxymethylfurfural,
b. root tissue of the plant Ophiopogon japonicus containing glucose, starch, vitamin A and .beta.-sitosterol,
c. root tissue of the plant Salvia miltiorrhiza containing tanshinone A C.sub.18 H.sub.12 O.sub.3, tanshinone B C.sub.19 H.sub.18 O.sub.3 and tanshinone C C.sub.19 H.sub.20 O.sub.3,
d. root tissue of the plant Angelica aeutiloba kitagawa containing ligustillide,
e. root tissue of the plant Rehmannia glutinosa Liboschitz containing rehmannin, xylitol, glucose, mannitol, iron, vitamin A and catalpol,
f. white stone-like material formed by bacteria on surface of underground root of tree Poria cocos wolf containing ergosterol,
g. ripe fruits of the plant Schizandra chinensis containing citral, schizandrin C.sub.23 H.sub.32 O.sub.6, vitamin A, vitamin C and d-ylangene,
h. root tissue of the plant Platycodon grandiflorum containing polygalacic acid platycoside, inulin and phytosterol,
i. root tissue of the plant Polygala tenuifolia containing tenuifolin, polygallitol C.sub.6 H.sub.12 O.sub.5 and onsicin C.sub.24 H.sub.47 O.sub.5,
j. dried seeds of the plant Zizyphus jujuba containing betulinic acid C.sub.30 H.sub.48 O.sub.3, betulin C.sub.30 H.sub.50 O.sub.2, .beta.-sitosterol, fatty acids, vitamin A and organic acids,
k. dried seeds of the plant Biota orientalis containing borneol and fatty acids,
1. root tissue of the plant Pueraria pseudo-hirsuta containing flavon, puerarin and daidzein,
m. root tissue of the plant Panax ginseng containing ginsenoside, panacene C.sub.15 H.sub.24, panaquilon C.sub.32 H.sub.56 O.sub.14, panaxin C.sub.23 H.sub.38 O.sub.10, organic acids, vitamin A, vitamin B.sub.1, vitamin B.sub.2, vitamin C, inorganic salts and starch,
n. root tissue of the plant Codonopsis pilosula containing alkaloid, saponin, protein, starch, vitamin B.sub.1 and vitamin B.sub.2,
o. root tissue of the plant Scrophularia ningpoensis containing harpagide, phytosterol, linoleic acid and alkaloid,
p. root tissue of the plant Glycyrrhiza uralensis containing glycyrrhizic acid, calcium salt, potassium salt, glycyrrhizin, glycyrrhizic acid, liquiritigenin C.sub.21 H.sub.22 O.sub.9, glucose, mannitol, malic acid and l-asparagine,
q. root tissue of the plant Panax pseudo-ginseng containing pseudo-ginseng A C.sub.30 H.sub.52 O.sub.10, pseudo-ginseng B C.sub.23 H.sub.38 O.sub.10 and flavon,
r. the whole plant Ganoderma japonicum containing amino acid, protein, sterol and alkaloid,
s. root tissue of the plant Coptis chinensis containing berberine C.sub.20 H.sub.19 O.sub.5 N, coptisine C.sub.19 H.sub.15 O.sub.5 N, palmatine C.sub.21 H.sub.23 O.sub.5 N and woorenine C.sub.20 H.sub.17 O.sub.5 N,
t. flower heads of the plant Chrysanthemum morifolium containing adenine C.sub.5 H.sub.5 N.sub.5, stachydrine C.sub.7 H.sub.13 NO, choline and oil, and
u. skins of the plant Phellodendron amurense containing berberine, obakunone C.sub.26 H.sub.30 O.sub.7, obakulactone C.sub.26 H.sub.30 O.sub.8 and dictammolactone C.sub.28 H.sub.30 O.sub.9 ;
II. a mixture of the aqueous extracts of:
I.a.,
I.b.,
I.c.,
I.d.,
I.e.,
I.f.,
I.g.,
I.h.,
I.i.,
I.k.,
I.l.,
I.m.,
I.n.,
I.o.,
I.p.,
I.q., and
I.r.;
III. a mixture of the aqueous extracts of:
I.a.,
I.b.,
I.c.,
I.d.,
I.e.,
I.f.,
I.g.,
I.h.,
I.i.,
I.k.,
I.l.,
I.m.,
I.o.,
I.p.,
I.r.,
I.s.,
I.t.;
and
IV. a mixture of finely divided:
1. root tissue of the plant Salvia miltiorrhiza containing tanshinone A C.sub.18 H.sub.12 O.sub.3, tanshinone B C.sub.19 H.sub.18 O.sub.3 and tanshinone C C.sub.19 H.sub.20 O.sub.3,
2. root tissue of the plant Panax pseudo-ginseng containing ginsenoside, panacene C.sub.15 H.sub.24, panaquilon C.sub.32 H.sub.56 O.sub.14, panaxin C.sub.23 H.sub.38 O.sub.10, organic acids, vitamin A, vitamin B.sub.1, vitamin B.sub.2, vitamin C, inorganic salts and starch,
3. root tissue of the plant Red ginseng containing ginsenoside, panacene C.sub.15 H.sub.24, panaquilon C.sub.32 J.sub.56 O.sub.14, panaxin C.sub.23 H.sub.38 O.sub.10, organic acids, vitamin A, vitamin B.sub.1, vitamin B.sub.2, vitamin C, inorganic salts and starch, and
4. Amber, a hard translucent fossil resin buried between roots of old trees, containing succinoabietinolic acid C.sub.40 H.sub.60 O.sub.5, succinogiluinic acid C.sub.24 C.sub.36 O.sub.2, succinoresinol, succinoabietinol C.sub.40 H.sub.60 O and fatty acids,
wherein, in composition I, the weight percentage of each plant tissue, based on the total weight of said plants from which said mixture of aqueous extracts is derived, is in the range of:
from about 5% to about 20% of a.;
from about 5% to about 20% of b.;
from about 5% to about 20% of c.;
from about 5% to about 20% of d.;
from about 5% to about 20% of e.;
from about 5% to about 16% of f.;
from about 1% to about 15% of g.;
from about 1% to about 6% of h.;
from about 1% to about 10% of i.;
from about 1% to about 10% of j.;
from about 1% to about 10% of k.;
from about 1% to about 10% of l.;
from about 1% to about 10% of m.;
from about 1% to about 20% of n.;
from about 1% to about 15% of o.;
from about 0.1% to about 2% of p.;
from about 1% to about 15% of q.;
from about 1% to about 10% of r.;
from about 1% to about 5% of s.;
from about 1% to about 10% of t.;
and
from about 1% to about 10% of u.;
wherein, in composition II, the weight percentage of each plant tissue, based on the total weight of said plants from which said mixture of aqueous extracts is derived, is in the range of:
from about 3% to about 15% of a.;
from about 3% to about 15% of b.;
from about 5% to about 20% of c.;
from about 3% to about 15% of d.;
from about 5% to about 20% of e.;
from about 5% to about 20% of f.;
from about 2% to about 15% of g.;
from about 1% to about 5% of h.;
from about 2% to about 15% of i.;
from about 2% to about 15% of j.;
from about 2% to about 5% of k.;
from about 2% to about 15% of l.;
from about 1% to about 10% of m.;
from about 2% to about 15% of n.;
from about 3% to about 15% of o.;
from about 0.1% to about 2% of p.;
from about 3% to about 15% of q.;
and
from about 3% to about 15% of r.;
wherein, in composition III, the weight percentage of each plant tissue, based on the total weight of said plants from which said mixture of aqueous extracts is derived, is in the range of:
from about 5% to about 20% of a.;
from about 2% to about 10% of b.;
from about 2% to about 10% of c.;
from about 2% to about 10% of d.;
from about 2% to about 10% of e.;
from about 2% to about 10% of f.;
from about 2% to about 10% of g.;
from about 2% to about 4% of h.;
from about 2% to about 10% of i.;
from about 2% to about 10% of j.;
from about 1% to about 5% of k.;
from about 2% to about 10% of l.;
from about 2% to about 8% of m.;
from about 2% to about 15% of o.;
from about 0.1% to about 2% of p.;
from about 2% to about 10% of r.;
from about 1% to about 5% of s.;
and
from about 1% to about 5% of t.;
and wherein, in composition IV, the weight percentage of each plant tissue, based on the total weight of said plants from which said mixture of finely divided tissue is derived, is in the range of:
from about 20% to about 60% of 1.;
from about 20% to about 60% of 2.;
from about 10% to about 30% of 3.;
and
from about 5% to about 20% of 4.

130 more elements