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US 5,587,490 AGranted
Method of inactivation of viral and bacterial blood contaminants
AssigneeCredit Managers Association of California
InventorsRaymond P. Goodrich, Jr., Matthew S. Platz, Nagender Yerram, Roger W. Hackett, Marjan van Borssum Waalkes, Christine M. Williams-Hughes, Victoria A. Wong
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Abstract
A compound is provided for inactivating viral, bacterial or other contamination in cells, body fluids or fractions thereof. The compound comprises a psoralen with a single substituent that is either a quaternary phosphonium or ammonium moiety, and at least one substituent that is a halogen. The compound selectively binds to the contaminant, and upon activation by irradiation, damages the contaminant.
Claims7
A compound of the formula:
- ##STR60## wherein X is an anionic counterion;
- R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are independently a halogen;
- H;
- linear or branched alkyl of 1-10 carbon atoms;
- linear or branched alkoxy of 1-10 carbon atoms;
- --(CH.sub.2).sub.m --O--(CH.sub.2).sub.p --Z.sup..cndot..R'R"R'" or --O--(CH.sub.2).sub.n --Z.sup..cndot..R'R"R'" wherein n, m and p are independently integers from 1 to 10 and R', R" and R'" are independently H or linear or branched alkyl of 1 to 10 carbon atoms with the proviso that only one of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 or R.sub.6 is --(CH.sub.2).sub.m --O--(CH.sub.2).sub.p --Z.sup..cndot..R'R"R'" or --O--(CH.sub.2).sub.n --Z.sup..cndot..R'R"R'", and at least one of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 or R.sub.6 is a halogen;
- and Z is N or P.
4 more elements
Dependencies are inferred from the claim text.