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US 5,587,070 AGranted
System for processing biological fluid
AssigneePall Corporation
InventorsDavid B. Pall, Thomas C. Gsell, Vlado I. Matkovich, Thomas Bormann
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Abstract
A system for collecting and processing donated blood comprises a first porous medium interposed between a blood collection bag and a satellite bag and a second porous medium interposed between the blood collection bag and another satellite bag. The porous media are leucocyte depletion media. The system may also include one or more of the following: a red cell barrier medium, a separation medium, a gas inlet, and a gas outlet. The system can be used to centrifuge whole blood into one or more components, and includes a means for protecting the system during centrifugation.
Claims32
A biological fluid processing system comprising:
- a first container;
- a first porous medium communicating with the first container and comprising a red cell barrier medium or a combined leukocyte depletion and red cell barrier medium, said red cell barrier medium being capable of separating a red cell-containing portion of a biological fluid from a non red cell-containing portion of the biological fluid;
- and
- a separation device downstream of, and communicating with, the first porous medium, said device comprising a housing and including a separation medium;
- said housing having an inlet, a first outlet, and a second outlet;
- said separation medium having a first surface and a second surface, and comprising at least one porous membrane, said separation medium being suitable for passing a biological fluid including plasma and at least one other component of the biological fluid along the first surface of the separation medium and for passing plasma through the separation medium,
- said separation medium positioned inside the housing to provide a first fluid flow path for the biological fluid from the inlet along the first surface of the separation medium to the first outlet, and a second fluid flow for passing plasma through the first and second surfaces of the separation medium to the second outlet.
4 more elements
A system comprising:
- a first container;
- a first porous medium communicating with the first container, said first porous medium comprising a leukocyte depletion medium;
- and
- a separation device downstream of, and communicating with, the first porous medium, said device comprising a housing and including a separation medium;
- said housing having an inlet, a first outlet, and a second outlet;
- said separation medium having a first surface and a second surface, and comprising at least one porous membrane, said separation medium being suitable for passing a biological fluid including plasma and at least one other component of the biological fluid along the first surface of the separation medium and for passing plasma through the separation medium,
- said separation medium positioned inside the housing to provide a first fluid flow path for the biological fluid from the inlet along the first surface of the separation medium to the first outlet, wherein said first fluid flow path includes at least one fluid flow channel which decreases in cross-sectional area and decreases in depth along the length of the channel from the inlet to the first outlet;
- and a second fluid flow path for passing plasma through the first and second surfaces of the separation medium to the second outlet.
5 more elements
A biological fluid processing system comprising:
- a first container;
- a first porous medium communicating with the first container, said first porous medium comprising a leukocyte depletion medium;
- and
- a separation device downstream of, and communicating with, the first porous medium, said device comprising a housing and including a separation medium;
- said housing having an inlet, a first outlet, and a second outlet;
- said separation medium having a first surface and a second surface, and comprising at least one porous membrane, said separation medium being suitable for passing a biological fluid including plasma and at least one other component of the biological fluid along the first surface of the separation medium and for passing plasma through the separation medium,
- said separation medium positioned inside the housing to provide a first fluid flow path for the biological fluid from the inlet along the first surface of the separation medium to the first outlet, wherein said first fluid flow path includes at least one fluid flow channel which comprises a serpentine flow channel;
- and a second fluid flow path for passing plasma through the first and second surfaces of the separation medium to the second outlet.
5 more elements
Dependencies are inferred from the claim text.