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US 5,585,108 AGranted
Formulations of oral gastrointestinal therapeutic agents in combination with pharmaceutically acceptable clays
AssigneeNanoSystems L.L.C.
InventorsStephen B. Ruddy, W. Mark Eickhoff, Gary Liversidge, Eugene R. Cooper
Life of this patent
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Abstract
Nanoparticulate crystalline therapeutic substances formulated with stabilizers and pharmaceutically acceptable clays to enhance contact between the crystalline therapeutic substances and the gastrointestinal tract and to provide extended therapeutic effect.
Claims4
An orally/rectally administrable therapeutic formulation comprising:
- of from about 4 to about 45% w/v of an essentially water-insoluble particulate drug having an effective average particle size of less than about 2,000 nm;
- of from about 0.1 to about 10% w/v of a bioadhesive surfactant stabilizer selected from the group consisting of:
- polyethylene-polypropylene glycol block polymers of the formula (i)
- (i) (polyethylene oxide)a-(polypropylene oxide)-(polyethylene oxide)c wherein
- a is 46, 52, 62, 75, 97, 98, 122 and 128;
- b is 16, 30, 35, 39, 47, 54 and 67;
- and
- c is 46, 52, 62, 75, 97, 98, 122 and 128;
- (ii) polyvinyl alcohol,
- (iii) polyvinyl pyrrolidone,
- (iv) hydroxypropyl methylcellulose, and
- (v) polyoxyethylene sorbitan mono-oleate;
- from about 0.1 to 10% w/v of a pharmaceutically acceptable clay selected from the group consisting of:
- montmorillonite, beidelite, nontronite, hectorite and saponite;
- from 0 to about 1% w/v of a secondary stabilizer selected from the group consisting of dioctylsulfosuccinate and sodium lauryl sulfate;
- and
- water to make 100% w/v.
14 more elements
Dependencies are inferred from the claim text.