Method for making vascular grafts
AssigneeC. R. Bard, Inc.
InventorsRaymond C. Duhamel, Stephen Eldridge, Barbara Kelley, Brendan McCrea
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Abstract
A method for forming vascular graft prostheses is described. In particular, the method relates to determining the carrying volume of a gelable material to fill the interstices of a fabric prosthesis, applying that carrying volume of gelable material to the prosthesis, and crosslinking the gelable material to form uniform gel-coated prostheses having low porosity.
Claims41
A method for fabricating a vascular prosthesis comprising the steps of:
- (a) providing a porous substrate comprising a textile tube having interstices,
- (b) providing a gelable material solution,
- (c) determining a carrying volume for the substrate of the gelable material solution,
- (d) loading the substrate with a volume of the gelable material solution equal to the carrying volume of the substrate, thereby filling the interstices of the substrate and providing a substrate containing gelable material, and
- (e) crosslinking the gelable material, thereby providing a substrate having a crosslinked gelled material contained within the interstices of the substrate and on its surface.
A method for fabricating a vascular prosthesis comprising the steps of:
- (a) providing a porous substrate comprising a textile tube having interstices,
- (b) providing a gelable material solution,
- (c) determining a carrying volume for the substrate of the gelable material solution,
- (d) contacting the substrate with a surfactant prior to loading the substrate with the gelable material solution,
- (e) loading the substrate with a volume of the gelable material solution equal to the carrying volume of the substrate, thereby filling the interstices of the substrate and providing a substrate containing gelable material,
- (f) crosslinking the gelable material, and
- (g) contacting the substrate containing gelable material with a humectant.
In the method of forming a vascular prosthesis which comprises a porous textile tube impregnated with a gelled material, the improvement which comprises determining a carrying volume for the porous textile tube of a gelable material solution, and impregnating in a single application the porous textile tube with the carrying volume of the gelable material solution.
A method for producing a vascular graft comprising a porous substrate impregnated with a biocompatible material, the method comprising the steps of:
- (a) immersing the substrate in a liquid bath,
- (b) exposing the-substrate to ultrasonic agitation,
- (c) removing the substrate from the bath,
- (d) drying the substrate, and
- (e) impregnating the substrate with a biocompatible material, by applying in a single application to the substrate a carrying volume for the substrate.
In the method of forming a vascular prosthesis, which comprises a porous textile tube having interstices by impregnating the vascular prosthesis with gelled material, the improvement which comprises
- applying in a single application to the porous textile tube a carrying volume for the porous textile tube of a gelable material to fill the interstices, and
- causing the gelable material to form a gel within the interstices.
Dependencies are inferred from the claim text.