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US 5,583,141 AGranted
Heterocyclic compounds and their use as angiotensin antagonists
AssigneeTakeda Chemical Industries, Ltd.
InventorsTakehiko Naka, Yoshiyuki Inada
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Abstract
The abstract isn’t available for this document.
Claims32
A compound or a salt thereof:
- ##STR71## wherein R.sup.1 is an optionally substituted hydrocarbon residue which is optionally bound through a hetero-atom;
- R.sup.2 is a group of the formula:
- ##STR72## wherein i is --O-- or --S-- and j is >c=0 or >c=S;
- R.sup.3 is optionally esterified or amidated carboxyl, tetrazolyl, trifluoromethanesulfonic amide, phosphoric acid or sulfonic acid, which may be protected with optionally substituted lower alkyl or acyl and the group of the formula ##STR73## has a structure selected from the group consisting of ##STR74## wherein in addition to R.sup.1 and R.sup.3, a methyl substituent may be provided, and wherein h is CH.sub.2, C.dbd.O, C.dbd.S, S--(O).sub.m, NR.sup.9 and O wherein m denotes an integer of 0-2 and R.sup.9 is hydrogen or lower(1-4C)alkyl, and excluding the compound 2-ethoxy-1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]meth yl]benzimidazole-7-carboxylic acid and its physiologically acceptable salts.
1 more element
A compound or a salt thereof of formula:
- ##STR80## wherein R.sup.1 is lower (C.sub.1-5) alkyl which may be bound through --O--, --NH-- or --S-- and which may be substituted with hydroxy, amino, N-lower (C.sub.1-4) alkylamino, N,N-di-lower (C.sub.1-4) alkylamino, halogen, lower (C.sub.1-4) alkoxy or lower (C.sub.1-4) alkylthio;
- R.sup.2 is a group of the formula:
- ##STR81## wherein i is --O-- or --S--and j is >c=0 or >c=S;
- R.sup.3 is optionally esterified or amidated carboxyl, tetrazolyl, trifluoromethanesulfonic amide, phosphoric acid or sulfonic acid, which may be protected with optionally substituted lower alkyl or acyl and the group of the formula ##STR82## has a structure selected from the group consisting of ##STR83## wherein in addition to R.sup.1 and R.sup.3, a methyl substituent may be provided, and excluding the compound 2-ethoxy-1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]meth yl]benzimidazole-7-carboxylic acid and its physiologically acceptable salts thereof.
1 more element
Dependencies are inferred from the claim text.