Back to results
US 5,578,639 AGranted
PLA.sub.2 inhibitors and their use for inhibition of intestinal cholesterol absorption
AssigneeWarner-Lambert Company
InventorReynold Homan
Life of this patent
Estimating the term…
Abstract
Certain compounds have been synthesized and found to be effective inhibitors of phospholipase A.sub.2 (PLA.sub.2), and thereby useful in the treatment of intestinal cholesterol absorption and the disease states arising therefrom, such as hypercholesterolemia and coronary artery disease.
Claims8
A method of treating atherosclerosis or coronary artery disease in a mammal suffering therefrom which comprises administering to said mammal an effective amount of a compound of the formula ##STR17## wherein:
- R.sub.1 and R.sub.4 independently are hydrogen, hydroxy, lower alkyl, halogen, trifluoromethyl, cyano, nitro, methylthio, lower alkenyl or lower alkynyl;
- R.sub.2 is hydrogen, lower alkyl, trifluoromethyl, lower alkenyl or lower alkynyl;
- R.sub.3 is hydrogen, lower alkyl, trifluoromethyl, lower alkenyl or lower alkynyl;
- or a pharmaceutically acceptable salt thereof.
1 more element
Dependencies are inferred from the claim text.