Graft copolymers of polycationic species and water-soluble polymers, and use therefor
AssigneeVivorx, Inc.
InventorsNeil P. Desai, Patrick Soon-Shiong, Paul A. Sandford, Roswitha E. Heintz
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Abstract
In accordance with the present invention, there are provided methods to render cells non-adhesive and/or non-immunogenic with respect to macromolecules typically encountered in culture media or in physiological media. The invention method comprises contacting cells with an effective amount of a composition comprising a polycationic species having water-soluble polymer chains grafted thereon.
Claims18
A method to render cells non-adhesive, said method comprising directly contacting a surface of said cells with an effective amount of a composition comprising a polycationic species having water-soluble polymer chains grafted thereon.
A method to render cells non-immunogenic, said method comprising directly contacting a surface of said cells with a composition comprising a polycationic species having water-soluble polymer chains grafted thereon.
A method for associating water-soluble polymer with a cell surface, said method comprising:
- grafting water-soluble polymer onto a polycationic resin to produce a copolymer, and thereafter
- directly contacting said cell surface with an effective amount of said copolymer.
Cells having a modified cell surface which is non-adhesive with respect to mediators of immune response, wherein the surface of said cells has been modified by directly contacting said surface with a composition comprising a polycationic species having water-soluble polymer chains grafted thereon.
Dependencies are inferred from the claim text.