Mucosal adhesive device for long-acting delivery of pharmaceutical combinations in oral cavity
AssigneeRutgers, The State University of New Jersey
InventorsYie W. Chien, Mona Nair
Life of this patent
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Abstract
Mucosal adhesive devices are provided for use in the oral cavity for therapy against infections. The devices are dosage units which comprise a combination of antimicrobial agents such as antifungal agents and anti-inflammatory agents, optionally also a local anesthetic. The dosage units yield a gradual and relatively constant release of the pharmaceuticals over at least a 12-hour period.
Claims8
A mucosal adhesive dosage unit adapted to use for treatment of oral cavity infection selected from a) the forms consisting of a dosage unit wherein mucoadhesive polymer layer having intermixed pharmaceuticals is adhered to a protective backing layer, and b) a tablet comprising a mucosal adhesive polymer mixture having intermixed pharmaceuticals;
- said mucosal adhesive dosage unit adhering to the oral mucosal tissue for at least about 12 hours,
- said mucosal adhesive dosage unit having a therapeutic dosage amount of one or more antimicrobial agents and one or more anti-inflammatory agents,
- said dosage unit releasing the antimicrobial agent and anti-inflammatory agent at a substantially constant rate for at least 12 hours to treat infection in the oral mucosa.
Dependencies are inferred from the claim text.