Method for preventing embryo implantation
AssigneeThe Trustees of the University of Pennsylvania
InventorBruce Lessey
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Abstract
Methods for detecting receptivity of mammalian endometrium to embryo implantation comprising obtaining a sample of the endometrium, contacting the endometrium with a monoclonal antibody for .beta..sub.3 and detecting .beta..sub.3 in the endometrium. The invention also provides for methods of diagnosing infertility in a mammal and methods of detecting the window of embryo implantation in endometrium. Methods of in vitro fertilization, methods of preventing embryo implantation and a method of monitoring endometrial maturation are also within the scope of the present invention. The present invention is also directed to contraceptives. Diagnostic kits useful in the practice of the methods of the invention are also provided.
Claims7
A method of blocking embryo implantation in a mammal comprising contacting the endometrium of said mammal with a neutralizing Fab fragment specific for the .beta..sub.3 subunit of integrin.
The method of blocking embryo implantation in a mammal comprising a contacting the endometrium of said mammal with a peptide containing the sequence arginine--glycine--aspartic acid.
Dependencies are inferred from the claim text.