Anti-ischemic 2,4-diaminoquinazolines
AssigneeEisai Co., Ltd.
InventorsYasutaka Takase, Nobuhisa Watanabe, Makoto Matsui, Hironori Ikuta, Teiji Kimura, Takao Saeki, Hideyuki Adachi, Tadakazu Tokumura, Hisatoshi Mochida, Yasunori Akita, Shigeru Souda
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Abstract
The invention is directed to certain 2,4-diaminoquinazoline compounds, their pharmaceutically acceptable salts, the pharmaceutical compositions comprising those compounds and their therapeutic methods of use. The compounds possess anti-ischemic activity.
Claims11
A compound, or the pharmacologically acceptable salt thereof, represented by the formula (I):
- ##STR796## wherein R1, R3, and R4, each of which may be the same or different from each other, may each represent a hydrogen atom, a halogen atom or a lower alkyl group or a lower alkoxy hydrogen atom, R2 is a halogen or cyan group R5 is a group represented by the formula:
- ##STR797## wherein u is 3 or 4 and R61 represents a carboxyl group which may be protected or a heteroaryl group;
- or R5 is a group represented by the formula:
- ##STR798## and R6 is a group represented by the formula ##STR799## wherein X is hydrogen atom or a halogen atom or ##STR800##
2-(4-carboxypiperidino)-4-(3,4-methylene-dioxybenzyl) amino-6-chloroquinazoline- or a pharmaceutically acceptable salt thereof.
Sodium 2-( 4-carboxypiperidino)-4-(3,4-methylene-dioxybenzyl) amino-6-chloroquinazoline.
Dependencies are inferred from the claim text.