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US 5,576,311 AGranted
Cyclodextrins as suspending agents for pharmaceutical suspensions
AssigneePharmos Corporation
InventorYaacov J. Guy
Life of this patent
Estimating the term…
Abstract
The present invention relates to stable aqueous suspension of drugs suitable for therapeutic administration without requiring solubilization or complexation of those drugs. The suspensions are stabilized with cyclodextrin type suspending agents. Stabilized suspensions of corticosteroids which employ these suspending agents are useful for therapeutic treatment of the eye, ear, or nose.
Claims25
A stable suspension of a drug comprising:
- an aqueous medium,
- component (A) of a therapeutic concentration of a drug in a particulate form that does not appreciably dissolve in the aqueous medium, and
- component (B) of a suspension agent comprising an amorphous cyclodextrin
- wherein the drug is retained in suspension in the aqueous medium without forming a soluble inclusion complex with the cyclodextrin.
1 more element
A composition for ophthalmic or otolaryngological anti-inflammatory use comprising a stable suspension of:
- an aqueous medium,
- a component (A) of corticosteroid in a particulate form that does not appreciably dissolve in the aqueous medium,
- a component (B) of a suspension agent comprising a cyclodextrin,
- wherein the molar ratio of (A):(B) is about 4:1 to 1:100 and the corticosteroid is retained in suspension in the aqueous medium without forming a water soluble inclusion complex with the cyclodextrin.
1 more element
Dependencies are inferred from the claim text.