Back to results
US 5,574,164 AGranted
1-alkyl-,1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds
AssigneeHoescht Roussel Pharmaceuticals Inc.
InventorsJohn J. Tegeler, Barbara S. Rauckman, Russell R. L. Hamer, Brian S. Freed, Gregory H. Merriman
Life of this patent
Estimating the term…
Abstract
Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and relieving memory dysfunction, and inhibiting bacterial and fungal growth are disclosed.
Claims5
A process for the preparation of a compound of the formula RCHO wherein R is
- wherein R.sup.5 is CH.sub.3 (CH.sub.2).sub.m C.tbd.C or ##STR62## wherein m is 9 to 15 and n is 0 to 12;
- R.sup.40 is alkyl or a group of the formula ##STR63## wherein W is as below;
- W and X are independently hydrogen, loweralkyl, loweralkoxy, halogen, or trifluoromethyl;
- with the proviso that when R is ##STR64## X is not hydrogen or loweralkyl Z is O;
- and A is O or S;
- which comprises contacting a compound of the formula RCHO wherein R is ##STR65## wherein R.sup.40, X, A and Z are as above and Y is halogen;
- with the compound of the formula CH.sub.3 (CH.sub.2).sub.m C.tbd.CH or ##STR66## wherein W, m and n are as above in the presence of bis(triphenylphosphine)palladiumdichloride and cuprous iodide and an acid acceptor.
4 more elements
Dependencies are inferred from the claim text.