US 5,573,934 AGranted

Gels for encapsulation of biological materials

AssigneeBoard of Regents, The University of Texas System

InventorsJeffrey A. Hubbell, Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Neil P. Desai, Jennifer L. Hill-West, Syed F. A. Hossainy

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Abstract

Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active materials. The polymeric materials are particularly useful as tissue adhesives, coatings for tissue lumens including blood vessels, coatings for cells such as islets of Langerhans, coatings, plugs, supports or substrates for contact with biological materials such as the body, and as drug delivery devices for biologically active molecules.

Claims16

Dependent claims

A method for encapsulating, sealing, coating or supporting a biological material comprising:

a) contacting a solution of a non-toxic free radical polymerization initiator selected from the group consisting of visible or long wavelength ultraviolet light-activatable free radical initiators, thermal activatable free-radical initiators with a biological material selected from the group consisting of mammalian cells, components of mammalian cells, aggregates of mammalian cells, and mammalian tissues, to allow binding of the initiator to the biological material;
b) removing the unbound initiator;
c) adding to the biological material a water soluble biocompatible macromer comprising at least two free radical polymerizable end groups, wherein the macromer is non-toxic and has a molecular weight of at least 400, and
d) exposing the mixture to an agent activating the initator to cause polymerization of the macromers to form a polymeric gel with a degree of polymerization greater than 10.

1 more element

Dependencies are inferred from the claim text.

Facts

Application: 08/024,657Filed 1 Mar 1993 · continuation in part
Priority: 20 Apr 1992
Granted: 12 Nov 1996
Term ends: Not estimatedThe source records don’t support an estimate.

Classification57 codes

C12N 11/04
Enzymes or microbial cells immobilised on or in an organic carrier: entrapped within the carrier, e.g. gel or hollow fibres
A61K 9/1635
Organic macromolecular compounds: obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, polyacrylates
A61K 9/1647
Obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers: polyesters, e.g. poly
A61K 9/5026
Organic macromolecular compounds: obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, polyacrylates