Bottle with closure element for receiving syringe and method therefor

In a medicament bottle having liquid medicament therein, wherein the bottle is formed with a neck defining an opening and a closed bottom distanced therefrom, a device for receiving a hub of a needleless syringe, comprising:

• a cap formed with a passageway therethrough, the cap being threadably engageable with the bottle to block the opening;
• a hollow fitting positioned in the passageway and configured for receiving the hub of the needleless syringe;
• a plug selectively engageable with the hollow fitting and formed with a plug end for blocking the hollow fitting and an engagement end attached to the cap;
• and
• a tube having a proximal end in fluid communication with the hollow fitting and a distal end positionable adjacent the bottom of the bottle,
• wherein the syringe can be engaged with the fitting for drawing liquid from the bottle into the syringe without inverting the bottom of the bottle over the neck of the bottle.