Methods for enhancing vascularization of implant devices
AssigneeBaxter International Inc.
InventorsLaura A. Martinson, James H. Brauker, Robert C. Johnson, Thomas Loudovaris
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Abstract
Methods for enhancing vascular support of cells housed within an implanted apparatus are disclosed. The methods comprise placing a population of therapeutic substance-producing cells into the cell receiving chamber of an immunoisolation apparatus, implanting the apparatus into a patient, and administering an immunomodulatory agent to the patient. The immunomodulatory agent increases the number of close vascular structures in the vicinity of the implanted device, which increases the long term survival of the cell population housed therein.
Claims14
A method for implanting cells in a patient, comprising the steps of:
- (a) providing a population of viable cells;
- (b) implanting into said patient an immunoisolation apparatus having structure defining a cell receiving chamber therein, said immunoisolation apparatus comprising an immunoisolation zone that immunoisolates said cell receiving chamber;
- (c) placing said population into said cell receiving chamber of said immunoisolation apparatus;
- and
- (d) administering an immunomodulatory agent to said patient in an amount and for a time effective to enhance vascularization of said implanted apparatus.
Dependencies are inferred from the claim text.