Non-steroidal sulfatase inhibitor compounds and their method of use

A method of therapeutically treating a patient for estrogen dependent diseases comprising employing a compound having the formula (1) ##STR9## wherein (a) R.sub.1 is selected from the group consisting of hydrogen and a lower alkyl group, (b) R.sub.2 is selected from the group consisting of H and a lower alkyl group, (c) m is an integer from 0 to 4, and (d) n is an integer from 5 to 14;

• incorporating said compound in a suitable pharmaceutical carrier;
• administering a therapeutically effective dosage of said compound incorporated in said carrier to said patient;
• and
• employing said method in therapeutically treating a patient for estrogen dependent diseases selected from the group consisting of breast cancer, ovarian cancer, vaginal cancer, endometrial cancer and endometriosis.

A method for preparing the compound comprising the formula (1) ##STR11## wherein R.sub.1 is selected from the group consisting of hydrogen and a lower alkyl group, R.sub.2 is selected from the group consisting of H and a lower alkyl group, m is an integer from 0 to 4 and n is an integer from 5 to 14, the method comprising:

• adding alkanoyl chloride dropwise into a cooled solution of p-hydroxyphenylamine and triethylamine to form a first mixture;
• extracting said first mixture to give a first product N-alkanoyl-p-hydroxyphenylamine;
• adding a hydride and a sulfamide to said first product to form a second mixture;
• extracting said second mixture to give a second product (p-o-sulfamoyl)-N-alkanoyl p-hydroxyphenylamine.