Collagen crosslinked with a crosslinking agent for the manufacture of a suturable, biocompatible slowresorbing membrane, and such a membrane
OwnerNabil Abdul-Malak, Jean Fourcart +1inventors
InventorsNabil Abdul-Malak, Jean Fourcart, Alain Huc
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Abstract
Suturable, biocompatible, control-resorbing membranes are disclosed for use in guided tissue regeneration, comprising a cross-linked collagen material either obtained by crosslinking a starting collagen material in the coagulated state produced by coagulation of a collagen material gel with a coagulating agent or obtained by crosslinking of a sponge of a collagen material on which a collagen material gel has been poured before performing the crosslinking.
Claims31
A process of manufacture of a suturable, biocompatible, controlled-resorbing, mixed membrane, comprising the following steps:
- a) preparing a sponge of a mixture of a collagen material and of a glycosaminoglycan;
- b) compressing said sponge under a pressure of about 150 bars;
- c) pouring a collage gel onto said sponge;
- and
- d) cross-linking said sponge with said collagen gel, with a cross-linking agent.
A suitable, bicompatible, controlled-resorbing membrane comprising a collagen material cross-linked with a cross-linking agent, wherein said cross-linked collagen material is obtained by cross-linking of a sponge of a collagen material which has been compressed under a pressure of about 150 bars and on which compressed sponge a collagen material gel has been poured before performing said cross-linking.
A process for guided tissue regeneration, comprising using a cross-linked collagen material as obtained by cross-linking a sponge of collagen material which has been compressed under a pressure of about 150 bars and on which compressed sponge, a collagen material gel has been poured before performing said cross-linking.
A process for guided tissue regeneration using a cross-linked collagen material, comprising:
- a) preparing a sponge of a collagen material;
- b) compressing the collagen material under a pressure of about 150 bars;
- and
- c) cross-linking the compressed sponge of collagen material.
A process for guided tissue regeneration using a cross-linked collagen material, comprising:
- (a) preparing a sponge of a collagen material;
- (b) compressing the sponge of collagen material under pressure of at least about 150 bars;
- (c) cross-linking the sponge of collagen material to provide a denaturation temperature of the cross-linked collagen material which is at least 15.degree. C. greater than a denuaturation temperature of a native collagen;
- and
- (d) drying the cross-linked sponge of collagen material in air.
Dependencies are inferred from the claim text.