Alkaline and acid phosphatase inhibitors in treatment of neurological disorders
AssigneeCortex Pharmaceuticals, Inc.
InventorsJudith A. Kelleher, David D. Eveleth
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Abstract
The present invention provides a method of inhibiting .beta.-amyloid toxicity in brain cells. The method includes administering to the cells an amount of an alkaline phosphatase inhibitor which is pharmacologically effective to reduce degeneration in the cells. Methods of treatment of peripheral neuropathy are also provided using acid or alkaline phosphatase inhibitors.
Claims19
A method of inhibiting .beta.-amyloid toxicity in brain cells exposed to .beta.-amyloid peptide, comprising:
- administering to said cells an arylimidothiazole derivative having nucleotide alkaline phosphatase inhibitory activity in an amount effective to reduce cell degeneration.
A method of treating a human subject having a peripheral neuropathy, comprising:
- administering to said subject an amount of a nucleotide alkaline phosphatase inhibitor which is pharmacologically effective to alleviate the symptoms of the peripheral neuropathy.
A method of treating a human subject having a peripheral neuropathy, comprising:
- administering to said subject an amount of an acid phosphatase inhibitor which is pharmacologically effective to alleviate the symptoms of the peripheral neuropathy.
Dependencies are inferred from the claim text.