Loading patent…
AssigneeEnteron, L.P.
InventorEmanuel Calenoff
Estimating the term…
A library of isolated and purified antigens specific for a microorganism is a set of individual molecules. The library forms antigen-antibody complexes useful in the context of diagnosing and treating conditions associated with a specific microorganism such as H. pylori-induced gastro-duodenal disease. For the antigen-antibody complexes in question the antibody is an immunoglobulin, which is IgE if the antigens are allergens. Complexes with IgA, IgG and IgM are also useful. By this multivariate approach, a specific condition is diagnosed with high sensitivity and specificity by determining whether complexes form between a specific antigen library and a biological sample which contains immunoglobulins from an individual. Such libraries also are useful for immunotherapy.
A method of detecting in an individual a condition associated with a microorganism, said microorganism selected from the group consisting of a bacterium, a virus, and a mycoplasma, said method comprising:
A method of measuring in a biological sample immunoglobulin E which complexes with a bacterial antigen library, the method comprising:
A method of determining whether an individual has an immunological response to a library of bacterial antigens, said library comprising purified and isolated antigens each having a homogenous molecular weight the method comprising:
A diagnostic kit comprising a library of isolated and purified microbial antigens from the same microorganism each antigen in solution in a suitable container, and means for detecting immunological complexes formed between the library of antigens from the same microorganism and immunoglobulin E in a biological sample.
Dependencies are inferred from the claim text.