Isolation of the calcium-phosphate crystals of bone
AssigneeChildren's Medical Center Corporation
InventorsMelvin J. Glimcher, Hyun-Man Kim, Christian Rey
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Abstract
The present invention is a process for first removing and isolating the calcium-phosphate crystals of bone from a substantial amount of the organic matrix and cellular constituents of bone without significant physical, chemical or structural alterations in the crystals. The crystals can then be further treated to remove the remaining amount of organic material associated with the crystals, leaving them essentially free of any of the organic constituents of bone, without significant physical, chemical or structural alterations in the crystals.
Claims18
A composition of calcium-phosphate apatite crystals essentially free of hydroxyl groups, and having essentially the same chemical composition, structure, short range order, and index of crystallinity as the calcium-phosphate crystals present in bone, wherein the bone is selected from the group consisting of bone, cartilage, cementum, dentin, and enamel.
Dependencies are inferred from the claim text.