# US 5,564,104 A · Methods of removing radioactively labled biological molecules from liquid radioactive waste

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- Number: US 5,564,104 A
- Document ID: US5564104A
- Status: Granted
- Kind: A
- Application number: 08/255,229
- Filed: 1994-06-07
- Granted: 1996-10-08
- Earliest claimed: 1993-06-08
- Assignees: Cortex Biochem, Inc.
- Inventors: Matt Pourfarzaneh
- Web page: https://patentgrep.com/patent/US5564104A

## CPC

- G21F 9/12: by absorption; by adsorption; by ion-exchange
- G21F: PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR (radiation protection by pharmaceutical means A61K8/00, A61Q17/04; in cosmonautic vehicles B64G1/54; combined with a reactor G21C11/00; combined with X-ray tubes H01J35/16; combined with X-ray apparatus H05G1/02)

## Abstract

This invention relates to the processing of liquid radioactive waste containing radioactively labeled biological molecules. More specifically, this invention relates to the use of solid phase binders to remove radioactively labeled biological molecules from liquid radioactive waste solutions.

## Claims

### Claim 1

A method of removing a radioactively labeled biological molecule from a liquid radioactive waste solution comprising the steps of:
(a) contacting said liquid radioactive waste solution with a magnetizable particle binder to form a magnetizable particle binder:radioactively labeled biological molecule complex; and
(b) separating said complex from said liquid radioactive waste solution by contacting said complex with a magnetic field to remove the radioactively labeled biological molecule from said liquid radioactive waste solution.

### Claim 2 (depends on 1)

The method of claim 1 wherein said magnetizable particle binder comprises adsorbent particles attached to a magnetizable polymer.

### Claim 3 (depends on 2)

The method of claim 2 wherein said adsorbent particles are charcoal particles.

### Claim 4 (depends on 2)

The method of claim 2 wherein said magnetizable polymer is a magnetizable polyacrylamide gel.

### Claim 5 (depends on 4)

The method of claim 4 wherein said magnetizable particle binder comprises charcoal particles entrapped in the magnetizable polyacrylamide gel.

### Claim 6 (depends on 5)

The method of claim 5 wherein said radioactively labeled biological molecule is a mixture of .sup.125 I folate and .sup.57 Co vitamin B12.

### Claim 7 (depends on 1)

The method of claim 1 wherein said magnetizable particle binder is a magnetizable particle immunochemical binder.

### Claim 8 (depends on 7)

The method of claim 7 wherein said magnetizable particle immunochemical binder comprises an antibody attached to a magnetizable polymers.

### Claim 9 (depends on 8)

The method of claim 8 wherein said magnetizable particle immunochemical binder comprises an antibody chemically coupled to a magnetizable cellulose polymer.

### Claim 10 (depends on 7)

The method of claim 7 further comprising the step of binding said radioactively labeled biological molecule to a liquid phase antibody, wherein said magnetizable particle immunochemical binder binds to said liquid phase antibody to form the solid phase binder:radioactively labeled biological molecule complex of step (a).

### Claim 11 (depends on 10)

The method of claim 10 wherein said magnetizable particle immunochemical binder comprises an antibody capable of binding to the liquid phase antibody.

### Claim 12 (depends on 11)

The method of claim 11 wherein said radioactively labeled biological molecule is .sup.125 I thyroxine, said liquid phase antibody is a mouse antithyroxine antibody, and the magnetizable particle immunochemical binder comprises a sheep anti-mouse antibody.