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US 5,563,176 AGranted
Illudin analogs useful as antitumor agents
AssigneeThe Regents of the University of California
InventorsMichael J. Kelner, Trevor C. McMorris, Raymond Taetle
Life of this patent
Estimating the term…
Abstract
Antineoplastic illudin analogs are provided of the formula: wherein R.sub.4, R.sub.5 and R.sub.6 are (C.sub.1 -C.sub.4)alkyl, Y is H, (C.sub.1 -C.sub.3)alkyl, (R.sub.4)R.sub.5)(R.sub.6)Si or alkanoyl ((C.sub.1 -C.sub.4)alkylC(O)) and R is CH.sub.2 OH, halo, benzyl optionally substituted with OY, or alkanoylmethyl (CH.sub.2 OC(O)R.sub.7), wherein R.sub.7 is (C.sub.1 -C.sub.4)alkyl, (C.sub.6 -C.sub.2)aryl or N(X).sub.2, wherein each X is H or (C.sub.1 -C.sub.4)alkyl, and the pharmaceutically-acceptable salts thereof.
Claims12
A compound of the formula (I):
- ##STR18## wherein R.sub.4, R.sub.5 and R.sub.6 are (C.sub.1 -C.sub.4)alkyl, Y is H (C.sub.1 -C.sub.3)alkyl, (R.sub.4)(R.sub.5)(R.sub.6)Si or (C.sub.1 -C.sub.4)alkylC(O) and R is CH.sub.2 OH, halo, benzyl optionally substituted with OY, CH.sub.2 OCH.sub.2 OH, or CH.sub.2 OC(O)R.sub.7, wherein R.sub.7 is (C.sub.1 -C.sub.4)alkyl, (C.sub.6 -C.sub.12)aryl or N(X).sub.2, wherein each X is H or (C.sub.1 -C.sub.2)alkyl, and the pharmaceutically-acceptable salts thereof.
Dependencies are inferred from the claim text.