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US 5,562,895 AGranted
Methods and compositions for mineralizing and flouridating calcified tissues
AssigneeAmerican Dental Association Health Foundation
InventorMing S. Tung
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AssigneeAmerican Dental Association Health Foundation
InventorMing S. Tung
Estimating the term…
The invention involves new compositions and methods of use and delivery of amorphous calcium compounds such as: amorphous calcium phosphate (ACP), amorphous calcium phoshate fluoride (ACPF), amorphous calcium carbonate phosphate (ACCP), amorphous calcium carbonate phosphate fluoride (ACCPF), and amorphous calcium fluoride (ACF) for use in remineralizing and fluoridating teeth. These amorphous compounds or solutions which form the amorphous compounds, when applied either onto or into dental tissue prevent and/or repair dental weaknesses such as dental caries, exposed roots and dentin sensitivity. The compounds have the highest solubilities, fastest formation rates and fastest conversion rates (to apatite) among all the calcium phosphates under physiological conditions. Moreover, in the presence to fluoride the amorphous compound convert rapidly to fluoride containing apatite.
A pressurized carbonated solution containing an acidic solution of a material more soluble in acidic solutions than in basic solutions, whereby when the pressure is released and carbon dioxide is removed, the acidity of the solution decreases and the material precipitates out of solution allowing for delivery of the material to a surface.
A nonaqueous dispersion of a carbonate salt and an acid, or acidic salt thereof, into a nonaqueous medium, whereby when the dispersion comes in contact with an aqueous solution the carbonate salt and the acid are dissolved into the solution, earben dioxide escapes from the solution decreasing the acidity of the solution and a material of desired qualities is precipitated from the solution onto a surface.
A pressurized carbonated solution containing an acidic solution of at least one amorphous calcium compound, whereby when the pressure is released and carbon dioxide is removed, the acidity of the solution decreases and the amorphous calcium compound precipitates out of solution onto and into dental tissue.
Dependencies are inferred from the claim text.