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US 5,561,220 AGranted
Technetium-99m labeled peptides for imaging inflammation
AssigneeDiatech, Inc.
InventorsRichard T. Dean, Brian R. Moyer
Life of this patent
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AssigneeDiatech, Inc.
InventorsRichard T. Dean, Brian R. Moyer
Estimating the term…
This invention relates to compositions that are radiolabeled scintigraphic imaging agents, comprising a polybasic compound covalently linked to a radiolabel binding moiety and the composition further comprising a polysulfated glycan. The invention also provides methods for producing and using such compositions. Specifically, the invention relates to compositions comprised of technetium-99m (Tc-99m) labeled scintigraphic imaging agents comprising a polybasic compound having at least 5 chemical functionalities that are basic at physiological pH and a radiolabel-binding moiety, the composition further comprising a polysulfated glycan, the composition being capable of specifically binding to inflammatory sites in vivo. Methods and kits for making such compositions, and methods for using such compositions to image sites of infection and inflammation in a mammalian body, are also provided.
A composition that is a scintigraphic imaging agent for imaging sites of inflammation within a mammalian body, the composition comprising a reagent comprised of a polybasic compound having a molecular weight of about 500 daltons to about 15,000 daltons and having at least 5 chemical functionalities that are basic at physiological pH, covalently linked to a technetium-99m binding moiety, the composition further comprising a polysulfated glycan having a molecular weight of about 1,000 daltons to about 60,000 daltons, wherein the reagent is radioactively labeled with technetium-99m, and wherein the composition is capable of binding to sites of inflammation in vivo.
A composition of matter having the formula:
Dependencies are inferred from the claim text.