Use of certain imidazol carbazols in treating stress-related manic-depressive disorders
AssigneeSandoz Ltd.
InventorsMoise Azria, Karl-Heinz Buchheit, Keith A. Dixon, G unther Engel, Rudolf K. A. Giger
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Abstract
Use of a mono or bicyclic carbocyclic, or heterocyclic carboxylic, acid ester or amide or an imidazolyl carbazol in the manufaccure of a medicament suitable for the treatment of stress-related psychiatric disorders, for increasing vigilance, for the treatment of rhinitis or serotonin-induced disorders and/or coadministration with another active agent to increase the bioavailability thereof, or for nasal administration.
Claims2
A method of improving impaired approach oriented behavior in the treatment of stress-related manic-depressive disorders comprising administering to a subject in need of such treatment a therapeutically effective amount of a compound of formula Ia:
- ##STR20## wherein R.sub.15 is hydrogen, (C.sub.1-10)alkyl, (C.sub.3-9)cycloalkyl, (C.sub.3-6)alkenyl, phenyl or phenyl(C.sub.1-3)alkyl and one of the groups R.sub.16, R.sub.17 and R.sub.18 is hydrogen, (C.sub.1-6)alkyl, (C.sub.3-7)cycloalkyl, (C.sub.2-6)alkenyl or phenyl(C.sub.1-3)alkyl, and the others independently are hydrogen or (C.sub.1-4)alkyl, which compound is in free base or pharmaceutically acceptable acid addition salt form.
Dependencies are inferred from the claim text.