Recombinant human cytomegalovirus containing foreign gene
AssigneeSyntro Corporation
InventorsLisa J. Hock, Mark D. Cochran, Richard D. Macdonald
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Abstract
The present invention provides a virus comprising a DNA sequence essential for replication of a human cytomegalovirus and at least one foreign DNA sequence adapted for expression in a host. The foreign DNA sequence may encode a human immunodeficiency virus anti-sense mRNA sequence or an antigenic polypeptide, e.g., a malarial surface antigen. Also provided are therapeutic compositions and vaccines which comprise the novel viruses of the present invention.
Claims12
A recombinant human cytomegalovirus which comprises a foreign DNA sequence inserted within the genomic DNA of human cytomegalovirus, wherein the foreign DNA sequence is inserted within the 5.4 kb BamHI fragment shown in FIG. 1 or within the 5.4 kb XhoI fragment shown in FIG. 2, and wherein the foreign DNA sequence is capable of being expressed in a host cell infected with the recombinant human cytomegalovirus.
Dependencies are inferred from the claim text.