Microprecipitation of nanoparticulate pharmaceutical agents

A process of preparing an aqueous dispersion of a pharmaceutical agent comprising:

• continuously providing a first solution comprising water and surface modifier or a mixture thereof,
• continuously providing a second solution comprising a pharmaceutical agent in aqueous base to mix with the first flow, and
• immediately neutralizing with an acid solution to precipitate nanoparticulate dispersion of said pharmaceutical agent as fine particle colloidal dispersions of said pharmaceutical agent, followed by a salt removal step by diafiltration or dialysis and then a step of concentrating the dispersion.

A process of preparing an aqueous dispersions of a pharmaceutical agent comprising:

• continuously providing a first solution comprising water and surface modifier or a mixture thereof into a solution comprising a pharmaceutical agent in aqueous base to form a first flow, and then neutralizing the first flow with a second flow of an acid solution at a desired pH to form a fine particle dispersion of a pharmaceutical agent,
• followed by a step of salt removal by diafiltration or dialysis and then a step of concentrating the said dispersion.

A process of preparing aqueous dispersions of a pharmaceutical agent comprising:

• continuously providing a first solution comprising water and surface modifier or a mixture thereof into a solution comprising a pharmaceutical agent in aqueous base to form a first flow, and then neutralizing the first flow with a second flow of an acid solution at a desired pH to form a fine particle dispersion of a pharmaceutical agent,
• followed by a step of salt removal by diafiltration or dialysis and then a step of concentrating the said dispersion.