Therapeutic, IL-6 antibody kits, and process for their preparation
AssigneeImmunotech
InventorsHerve Brailly, Felix A. Montero-Julian, Bernard Klein
Life of this patent
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Abstract
A therapeutic kit which includes at least three unlinked monoclonal antibodies for neutralizing a short life IL-6 cytokine and a method for preparing said kit.
Claims10
A therapeutic kit for neutralizing a short life IL-6 cytokine, said cytokine being of sufficient size to comprise at least three functional antibody-binding sites, wherein said kit includes at least three unlinked individual monoclonal antibodies which have an affinity greater than 10.sup.9 liter/mole and bind three distinct epitopes of said cytokine, at least one of the said three monoclonal antibodies blocking the biological activity of said cytokine as evaluated in vitro with the aid of a biological assay measuring IL-6 activity.
Dependencies are inferred from the claim text.