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US 5,557,032 AGranted
Knockout mice
AssigneesThe Ontario Cancer Institute, Craig Bernie Thompson
InventorTak W. Mak
Life of this patent
Estimating the term…
Abstract
Mice lacking expression of CD28 or particular CD45 isoforms in certain cells of the immune system are provided. Also provided are methods of using these mice.
Claims3
A mutant mouse, wherein its endogenous CD28 gene has been disrupted by homologous recombination using a DNA construct comprising intron 1 and exon 2 of the CD28 gene, and wherein a marker sequence is inserted into exon 2, and wherein said disruption prevents expression of CD28 on its T-cells and results in a decreased IgG titer upon viral infection.
Dependencies are inferred from the claim text.