Catalytic enantioselective synthesis of .alpha.-amino acid derivatives by phase-transfer catalysis
AssigneeIndiana University Foundation
InventorsMartin J. O'Donnell, Shengde Wu, Irena Esikova, Aiqiao Mi
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Abstract
Described are improved processes for the enantioselective synthesis of .alpha.-amino acids which involve combinations of solvents, highly-mixed and low-temperature reaction conditions, and novel catalysts. Also described are novel catalysts and precursors to .alpha.-amino acid derivatives.
Claims7
A compound useful as an enantioselective catalyst, comprising an N-substituted O-substituted cinchoninium or cinchonidinium halide or a 3a,3b-dihydro N-substituted O-substituted cinchoninium or cinchonidinium halide, wherein the N-substituent is alkyl-aryl wherein the alkyl is C.sub.1 to C.sub.5 and the aryl is up to C.sub.30, and the O-substituted is C.sub.1 to about C.sub.10 alkyl or alkenyl.
Dependencies are inferred from the claim text.