US 5,554,752 A · Spirovesamicols

Abstract

The compounds are vesamicol (hydroxylated phencyclidine (PCP) isomer trans-2-(4-phenyl-piperidino)cyclohexanol) derivatives with anticholinergic properties termed herein "spirovesamicols" which are spirofused piperidines. The compounds bind to the vesamicol receptor, a site on the cholinergic synaptic vesicle, which is associated with the vesicular transporter of acetylcholine.

Claims1

Dependent claims

A compound capable of binding to a vesamicol receptor selected from:

##STR1## wherein X is --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, (CH.sub.2).sub.3, --CY.dbd.CZ--, --CHY--CHZ--;
Y is H, halogen;
Z is H, halogen;
R is H or halogen;
P is phenyl, substituted phenyl;
and
Q is an alkylene chain having between 0 and 4 carbons.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

08/405,491Filed 14 Mar 1995 · division

Priority

5 Oct 1993

Granted

10 Sep 1996

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

A61K 51/0457
Having six-membered rings with one nitrogen as the only ring hetero atom: vesamicol
C07D 221/20
Condensed with carbocyclic rings or ring systems: spiro-condensed ring systems
C07D 401/04
Containing two hetero rings: directly linked by a ring-member-to-ring-member bond
A61K 2123/00
Preparations for testing in vivo

Abstract

Claims1

Dependent claims

A compound capable of binding to a vesamicol receptor selected from:

##STR1## wherein X is --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, (CH.sub.2).sub.3, --CY.dbd.CZ--, --CHY--CHZ--;
Y is H, halogen;
Z is H, halogen;
R is H or halogen;
P is phenyl, substituted phenyl;
and
Q is an alkylene chain having between 0 and 4 carbons.

4 more elements

Dependencies are inferred from the claim text.

Spirovesamicols

Life of this patent

Abstract

Claims1

Spirovesamicols

Life of this patent

Abstract

Claims1