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US 5,552,418 AGranted
Trisubstituted Naphthylalkylamides
AssigneeAdir et Compagnie
InventorsPatrick Depreux, Hamid Ait Mansour, Daniel Lesieur, Fran.cedilla.ois Lefoulon, Pierre Renard, G erard Adam, Philippe Delagrange
Life of this patent
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Abstract
The invention relates to a compound selected from those of formula (I): ##STR1## in which R, R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification, and a medicinal product containing said compound for treating a disorder of the melatoninergic system.
Claims4
A compound selected from those of formula (I):
- ##STR28## in which:
- R represents hydrogen or a radical chosen from alkyl, substituted alkyl and --O--R';
- with R' representing hydrogen or a radical selected from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloalkylalkyl, substituted cycloalkylalkyl, phenyl, substituted phenyl, phenylalkyl, substituted phenylalkyl, diphenylalkyl and substituted diphenylalkyl;
- R.sub.1 represents hydrogen or alkyl;
- R.sub.2 means a) ##STR29## in which X.sup.1 represents sulfur or oxygen and R.sub.40 represents hydrogen or a radical chosen from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloalkylalkyl, substituted cycloalkylalkyl, alkenyl, substituted alkenyl, alkynyl and substituted alkynyl;
- or b) ##STR30## in which X.sup.2 represents sulfur or oxygen and R.sub.41 represents hydrogen or a radical chosen from alkyl, cycloalkyl and cycloalkylalkyl;
- R.sub.3 represents a radical chosen from:
- R.sub.5 -alkyl-, with R.sub.5 being substituted or unsubstituted and representing pyridyl,
- R.sub.6 --CO--O--,
- and R.sub.6 --CO--,
- with R.sub.6 representing a radical chosen from R.sub.5 - and R.sub.5 -alkyl- where R.sub.5, being unsubstituted or substituted, is as defined above,
- the terms "alkyl" and "alkoxy" inclusively denoting, except where otherwise mentioned, linear or branched groups of 1 to 6 carbon atoms,
- the terms "alkenyl" and "alkynyl" inclusively denoting unsaturated, linear or branched groups of 2 to 6 carbon atoms,
- the term "cycloalkyl" inclusively denoting a cyclic group of 3 to 8 carbon atoms,
- the term "substituted" applied to "alkyl", "alkoxy", "alkenyl", "alkynyl", "cycloalkyl" or "cycloalkylalkyl" means that these groups are substituted with one or more radicals chosen from alkyl, alkoxy and halogen;
- the term "substituted" associated with R.sub.5 and with "phenyl", "phenylalkyl" or "diphenylalkyl" means that these groups are substituted with one or more radicals chosen from alkyl, alkoxy, halogen, hydroxyl and trifluoromethyl;
- their enantiomers and diastereoisomers,
- and their addition salts with a pharmaceutically-acceptable acid or base.
15 more elements
Dependencies are inferred from the claim text.