Surface modified NSAID nanoparticles
AssigneeNanoSystems L.L.C.
InventorsGary G. Liversidge, Philip Conzentino, Jr., Kenneth C. Cundy, Pramod P. Sarpotdar
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Abstract
Dispersible particles consisting essentially of a crystalline NSAID having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm. Pharmaceutical compositions containing the particles exhibit reduced gastric irritation following oral administration and/or hastened onset of action.
Claims13
Particles consisting essentially of 99.9-10% by weight of crystalline NSAID having a solubility in water of less than 10 mg/ml, said NSAID having a non-crosslinked surface modifier adsorbed on the surface thereof in an amount of 0.1-90% by weight and sufficient to maintain an average particle size of less than about 400 nm.
A method of hastening onset of action following administration to a mammal of pharmaceutical composition, said method comprising administering said pharmaceutical composition in the form of particles consisting essentially of 99.9-10% by weight of a crystalline drug substance having a solubility in water of less than 10 mg/ml, said drug substance having a non-crosslinked surface modifier adsorbed on the surface thereof in an amount of 0.1-90% by weight and sufficient to maintain an average particle size of less than about 400 nm.
Dependencies are inferred from the claim text.