Hepatocyte growth factor variants
AssigneeGenentech, Inc.
InventorsPaul J. Godowski, Natalie A. Lokker, Melanie R. Mark
Life of this patent
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Abstract
The invention concerns hepatocyte growth factor (HGF) amino acid sequence variants. The preferred variants are resistant to proteolytic cleavage by enzymes capable of in vivo conversion of HGF into its two-chain form and/or contain a mutation within the protease domain of HGF.
Claims20
A nucleotide sequence encoding a hepatocyte growth factor (HGF) variant, said variant comprising a polypeptide comprising an alpha chain and a beta chain, said alpha chain and said beta chain being connected and being resistant to proteolytic cleavage by enzymes that are capable of in vivo conversion of HGF into said alpha chain and said beta chain.
A nucleotide sequence encoding a human hepatocyte growth factor (huHGF) variant, said variant comprising a polypeptide comprising an alpha chain and a beta chain, said alpha chain and said beta chain being connected and being resistant to proteolytic cleavage by enzymes that are capable of in vivo conversion of huHGF into said alpha chain and said beta chain.
Dependencies are inferred from the claim text.