Controlling nitrogen oxide concentrations to modulate skeletal muscle contraction
AssigneesDuke Univ., Harvard College
InventorsJonathan Stamler, Lester Kobzik
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Abstract
A method for inhibiting or relaxing skeletal muscle contractions and for treating disease states resulting from or exacerbated by undesirable skeletal muscle contractions by administering a skeletal muscle relaxing amount of nitroxyl ion(NO.sup.-), nitrosonium ion(NO.sup.+), nitric oxide and nitric oxide adducts or providers. A process for stimulating, improving or enhancing muscle contraction in a mammal by treating the mammal with an effective amount of (i) a nitric oxide synthase inhibitor or (ii) a nitric oxide scavenger.
Claims7
A method for treating a mammal by stimulating the contraction of skeletal muscle of said mammal comprising:
- treating a mammal in need of treatment for amyotrophic lateral sclerosis, muscular dystrophies, congestive heart failure, or lung diseases by contraction of skeletal muscle by administering to said mammal a skeletal muscle contracting amount of a nitric oxide synthase inhibitor.
A process for enhancing skeletal muscle contraction in a mammal in need thereof comprising:
- treating the mammal in need of skeletal muscle contraction enhancement with an amount of a heme-containing compound effective to enhance skeletal muscle contraction in said mammal.
A method for stimulating the contraction of skeletal muscle in a mammal in need thereof comprising administering to said mammal in need thereof a skeletal muscle contraction enhancing amount of a nitric oxide scavenger.
Dependencies are inferred from the claim text.