Adenoviruses having modified fiber proteins
AssigneeGenetic Therapy, Inc.
InventorsAlan McClelland, Susan C. Stevenson
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Abstract
An adenovirus wherein the adenovirus fiber protein includes a ligand which is specific for a receptor located on a desired cell type. The adenovirus may have at least a portion of the adenovirus fiber protein removed and replaced with a ligand which is specific for a receptor located on a desired cell type, or the adenovirus may include a fusion protein of the adenovirus fiber protein and the ligand. Such an adenovirus may also include a gene(s) encoding a therapeutic agent(s) and may be "targeted" in order to deliver such gene(s) to a desired cell type.
Claims35
An adenovirus wherein at least a portion of the adenovirus fiber protein is removed and replaced with a ligand which is specific for a receptor located on a desired cell type.
An adenovirus including a fusion protein of an adenovirus fiber protein and a ligand which is specific for a receptor located on a desired cell type.
An adenoviral vector wherein DNA encoding a portion of the fiber protein of the adenovirus is removed and is replaced with DNA encoding a ligand which is specific for a receptor located on a desired cell type.
An adenoviral vector including a DNA sequence comprised of DNA encoding an adenovirus fiber protein operatively linked to DNA encoding a ligand which is specific for a receptor located on a desired cell type.
Dependencies are inferred from the claim text.