Phosphine containing amino acids and peptides and methods of preparing and using same
AssigneeWashington University
InventorScott R. Gilbertson
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Abstract
A method for incorporating novel phosphine containing amino acids into peptide sequences is provided. The resulting phosphine-containing peptides can be used to bind a transition metal between two phosphine moieties presented on an amino acid in a peptide. The resulting phosphine-containing peptide metal complex is useful as a stereoselective catalyst of a chemical reaction or as a means for delivering a metal selectively to a target tissue or organ for medical uses.
Claims21
A method of preparing a phosphine-containing peptide sequence, said method comprising the steps of:
- providing a peptide sequence containing at least one amino acid having a phosphine sulfide moiety bonded to the side chain of said amino acid;
- and
- reacting said peptide sequence with a reducing agent to convert said phosphine sulfide moiety on said amino acid in said peptide sequence to a phosphine moiety to yield a phosphine-containing peptide sequence.
A composition comprising an amino acid having a phosphine moiety bonded to the side chain of the amino acid.
A composition comprising a peptide containing at least one phosphine-containing amino acid.
A peptide having the amino acid sequence identified as SEQ ID NO. 1.
A peptide having the amino acid sequence identified as SEQ ID NO. 2.
A peptide-metal complex comprising a peptide or mixture of peptides, each containing at least one phosphine containing amino acid and a transition metal bonded between two phosphine-containing amino acids.
A method for producing a chiral end product of a chemical reaction comprising utilizing an asymmetric phosphine-peptide metal complex as the catalyst for said reaction.
Dependencies are inferred from the claim text.