Sulfonylaminopyrimidines

A pharmaceutical composition comprising an effective amount of a compound of the formula ##STR5## wherein R.sup.1 -R.sup.3 each independently are hydrogen, lower-alkyl, lower-alkoxy, lower-alkylthio, lower-alkenyl, halogen, trifluoromethyl, hydroxy-lower-alkoxy, halo-lower-alkoxy, cyclo-lower-alkyl, hydroxy-lower-alkanoylamino-lower-alkoxy, alkanoylamino-lower-alkyl, carboxy-lower-alkoxy, carboxy-lower-alkyl, lower-alkoxy-carbonyl-lower-alkyl, lower-alkoxycarbonyl-lower-alkoxy, alkanoyloxy-lower-alkoxy, alkanoyloxy-lower-alkyl, alkoxycarbonyl, carboxy, amino, mono- or di-(lower-alkyl)amino or a residue (R.sup.c,R.sup.d)N--C(O)(CH.sub.2).sub.0-4 O-- or (R.sup.c,R.sup.d)N--C(O)(CH.sub.2).sub.0-4 --;

• R.sup.2 and R.sup.3 together are butadienyl, methylenedioxy,ethylenedioxy or isopropylidenedioxy;
• R.sup.4 is hydrogen, lower-alkyl, cyclo-lower-alkyl, trifluoromethyl, lower-alkoxy, lower-alkinyloxy, lower-alkylthio, lower-alkylthio-lower-alkyl, lower-alkylthio-lower-alkoxy, hydroxy-lower-alkyl, hydroxy-lower-alkoxy, dihydroxy-lower-alkoxy, lower-alkoxy-lower-alkyl, hydroxy-lower-alkoxy-lower-alkyl, lower-alkoxy-lower-alkoxy, di(lower-alkoxy)-alkoxy, hydroxy-lower-alkoxy-lower-alkoxy, lower-alkylsulphinyl, lower-alkylsulphinyl-lower-alkoxy, lower-alkylsulphonyl, 2-methoxy-3-hydroxypropoxy, 2-hydroxy-3-phenylpropyl, amino-lower-alkyl, lower-alkylamino-lower-alkyl, di-lower-alkylamino-lower-alkyl, amino, lower-alkylamino, di-lower-alkylamino, arylamino, aryl, arylthio, aryloxy, aryl-lower-alkyl, aryl-lower-alkoxy-lower-alkyl, aryl-lower-alkyl-lower-alkoxy, heterocyclyl, heterocyclyl-lower-alkyl or heterocyclyl-lower-alkoxy, wherein heterocyclyl is a unsubstituted heterocyclyl selected from 2-furyl, 3-furyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridyl N-oxide, 1,2-diazinyl, 1,4-diazinyl, morpholino, thiomorpholino, thiomorpholino-4,4-dioxide, 2,2-dimethyl-1,3-dioxolanyl, 2-thienyl, 3-thienyl, isoxazolyl, oxazolyl, thiazolyl, imidazolyl, pyrrolyl, pyrrolidinyl, piperidinyl, azepanyl, benzofuranyl, benzothienyl, indolyl, purinyl, quinolyl and isoquinolyl or heterocyclyl as defined above mono or disubstituted by lower alkyl, lower alkoxy or halogen and wherein aryl is unsubstituted phenyl or phenyl substituted with halogen, lower-alkyl, lower-alkoxy, lower-alkylenedioxy, carboxy, or trifluoromethyl;
• R.sup.5 to R.sup.9 each independently are hydrogen, halogen, trifluoromethyl, lower-alkyl, lower-alkoxy, lower-alkylthio, lower-alkylsulphinyl or lower-alkylsulphonyl;
• R.sup.6 and R.sup.5 or R.sup.7 together are butadienyl, methylene dioxy, ethylenedioxy or isopropylidenedioxy;
• R.sup.a and R.sup.b each independently are hydrogen, lower-alkyl, lower-alkoxy or lower-alkylthio;
• R.sup.c and R.sup.d each independently are hydrogen, lower-alkyl or aryl;
• or R.sup.c and R.sup.d together with the N atom to which they are attached are a unsubstituted heterocyclyl selected from 2-furyl, 3-furyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridyl N-oxide, 1,2-diazinyl, 1,4-diazinyl, morpholino, thiomorpholino, thiomorpholino-4,4-dioxide, 2,2-dimethyl-1,3-dioxolanyl, 2-thienyl, 3-thienyl, isoxazolyl, oxazolyl, thiazolyl, imidazolyl, pyrrolyl, pyrrolidinyl, piperidinyl, azepanyl, benzofuranyl, benzothienyl, indolyl, purinyl, quinolyl and isoquinolyl or heterocyclyl as defined above mono or disubstituted by lower alkyl, lower alkoxy or halogen;
• Y is a residue --OC(O)NR.sup.10 R.sup.11, --NHC(O)NR.sup.10 R.sup.11, --OC(O)R.sup.10 or --NHC(O)OR.sup.10 ;
• R.sup.10 is lower-alkyl, cyclo-lower-alkyl, hydroxy-lower alkyl, carboxy-lower-alkyl, lower-alkoxycarbonyl-lower-alkyl, lower-alkanoyloxy-lower-alkyl, aryl, aryl-lower-alkyl, arylcarbamoyl-lower-alkyl, heterocyclyl, heterocyclyl-lower-alkyl or a residue (R.sup.c,R.sup.d)N--C(O)(CH.sub.2).sub.1-4 wherein heterocyclyl is a unsubstituted heterocyclyl selected from 2-furyl, 3-furyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridyl N-oxide, 1,2-diazinyl, 1,4-diazinyl, morpholino, thiomorpholino, thiomorpholino-4,4-dioxide, 2,2-dimethyl-1,3-dioxolanyl, 2-thienyl, 3-thienyl, isoxazolyl, oxazolyl, thiazolyl, imidazolyl, pyrrolyl, pyrrolidinyl, piperidinyl, azepanyl, benzofuranyl, benzothienyl, indolyl, purinyl, quinolyl and isoquinolyl or heterocyclyl as defined above mono or disubstituted by lower alkyl, lower alkoxy or halogen and wherein aryl is unsubstituted phenyl or phenyl substituted with halogen, lower-alkyl, lower-alkoxy, lower-alkylenedioxy, carboxy, or trifluoromethyl;
• and
• R.sup.11 is hydrogen or a residue R.sup.10 ;
• Z is --O--, --S-- or --CH.sub.2 --;
• X is --O--, --S-- or --NH--;
• n is 0 or 1;
• and
• m is 1, 2 or 3, or a pharmaceutically usable salt thereof;
• and an inert carrier.