Chimeric rhinoviruses
AssigneeRutgers University
InventorsEdward V. Arnold, Gail F. Arnold
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Abstract
Recombinant chimeric human rhinovirus and method for stimulation of a specific immune response. Design considerations, methods, and examples are described. Chimeric rhinoviruses can be used as vaccines and for a variety of other immunotechnological applications.
Claims26
Biologically pure recombinant chimeric human rhinovirus constructed by inserting into the human rhinovirus 14 (HR14) nucleotide sequence encoding part of a neutralizing immunogenic site, a heterologous nucleotide sequence encoding the chimeric region, wherein the chimeric region is expressed on the surface of the chimeric rhinovirus and is capable of participating in an immune reaction.
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