Sustained release formulations of water soluble peptides
AssigneeSandoz Ltd.
InventorsDavid Bodmer, Jones W. Fong, Thomas Kissel, Hawkins V. Maulding, Jr., Oskar Nagele, Jane E. Pearson
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Abstract
The invention discloses microparticles comprising a polypeptide, preferably somatostatin or an analog or derivative thereof, more preferably octreotide, in a polymeric matrix, preferably poly(lactide-co-glycolide) glucose. The invention also discloses sustained release formulations containing said microparticles and the use of said formulations in treating acromegaly and breast cancer.
Claims12
A microparticle having a diameter of between 1 and 250 microns comprising octreotide in a free base, acid addition salt or complex form, in a biodegradeable, biocompatible polymeric matrix of a 40/60 to 60/40 polylactide-co-glycolide ester of a polyol, said polyol being selected from the group consisting of 1) a (C.sub.3-6) carbon chain containing alcohol having 3 to 6 hydroxyl groups, 2) a mono-saccharide and 3) a di-saccharide, and said esterified polyol having at least 3 polylactide-co-glycolide chains, wherein said octreotide is present in an amount from 0.2 to 20 percent by weight relative to said polymeric matrix and said octreotide is distributed throughout said polymeric matrix.
Dependencies are inferred from the claim text.